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Available studies (70 found)
| Short citation | Full citation | Bioassay | Epidemiology | Epi. meta-analysis | In vitro | Ecology |
|---|---|---|---|---|---|---|
| Adamsson et al. 2009 | Adamsson A et al. Effects of maternal exposure to di-isononylphthalate (DINP) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) on steroidogenesis in the fetal rat testis and adrenal gland. Reprod. Toxicol. 2009; 28 (1):66-74. PubMed DOI | |||||
| Ahmad et al. 2014 | Ahmad R et al. Effects of in utero di-butyl phthalate and butyl benzyl phthalate exposure on offspring development and male reproduction of rat. Environ Sci Pollut Res Int 2014; 21 (4):3156-65. PubMed DOI | |||||
| Andrade et al. 2006 | Andrade AJ et al. A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): effects on androgenic status, developmental landmarks and testicular histology in male offspring rats. Toxicology 2006; 225 (1):64-74. PubMed | |||||
| Ashby et al. 1997 | Ashby J et al. Normal sexual development of rats exposed to butyl benzyl phthalate from conception to weaning. Regul. Toxicol. Pharmacol. 1997; 26 (1 Pt 1):102-18. PubMed | |||||
| Aso et al. 2005 | Aso S et al. A two-generation reproductive toxicity study of butyl benzyl phthalate in rats. J Toxicol Sci 2005; 30 Spec No. ():39-58. PubMed | |||||
| Barlow et al. 2004 | Barlow NJ, McIntyre BS, and Foster PM. Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to di(n-butyl) phthalate. Toxicol Pathol ; 32 (1):79-90. PubMed | |||||
| Beverly et al. 2014 | Beverly BE et al. Simvastatin and dipentyl phthalate lower ex vivo testicular testosterone production and exhibit additive effects on testicular testosterone and gene expression via distinct mechanistic pathways in the fetal rat. Toxicol. Sci. 2014; 141 (2):524-37. PubMed DOI | |||||
| Boberg et al. 2011 | Boberg J et al. Reproductive and behavioral effects of diisononyl phthalate (DINP) in perinatally exposed rats. Reprod. Toxicol. 2011; 31 (2):200-9. PubMed DOI | |||||
| Borch et al. 2004 | Borch J et al. Steroidogenesis in fetal male rats is reduced by DEHP and DINP, but endocrine effects of DEHP are not modulated by DEHA in fetal, prepubertal and adult male rats. Reprod. Toxicol. ; 18 (1):53-61. PubMed | |||||
| Borch et al. 2006 | Borch J et al. Mechanisms underlying the anti-androgenic effects of diethylhexyl phthalate in fetal rat testis. Toxicology 2006; 223 (1-2):144-55. PubMed | |||||
| Christiansen et al. 2009 | Christiansen S et al. Synergistic disruption of external male sex organ development by a mixture of four antiandrogens. Environ. Health Perspect. 2009; 117 (12):1839-46. PubMed DOI | |||||
| Christiansen et al. 2010 | Christiansen S et al. Low-dose perinatal exposure to di(2-ethylhexyl) phthalate induces anti-androgenic effects in male rats. Reprod. Toxicol. 2010; 30 (2):313-21. PubMed DOI | |||||
| Clewell et al. 2009 | Clewell RA et al. Kinetics of selected di-n-butyl phthalate metabolites and fetal testosterone following repeated and single administration in pregnant rats. Toxicology 2009; 255 (1-2):80-90. PubMed DOI | |||||
| Clewell et al. 2013 | Clewell RA et al. A dose response study to assess effects after dietary administration of diisononyl phthalate (DINP) in gestation and lactation on male rat sexual development. Reprod. Toxicol. 2013; 35 ():70-80. PubMed DOI | |||||
| Culty et al. 2008 | Culty M et al. In utero exposure to di-(2-ethylhexyl) phthalate exerts both short-term and long-lasting suppressive effects on testosterone production in the rat. Biol. Reprod. 2008; 78 (6):1018-28. PubMed DOI | |||||
| Do et al. 2012 | Do RP et al. Non-monotonic dose effects of in utero exposure to di(2-ethylhexyl) phthalate (DEHP) on testicular and serum testosterone and anogenital distance in male mouse fetuses. Reprod. Toxicol. 2012; 34 (4):614-21. PubMed DOI | |||||
| Drake et al. 2009 | Drake AJ et al. Glucocorticoids amplify dibutyl phthalate-induced disruption of testosterone production and male reproductive development. Endocrinology 2009; 150 (11):5055-64. PubMed DOI | |||||
| Ema and Miyawaki 2002 | Ema M and Miyawaki E. Effects on development of the reproductive system in male offspring of rats given butyl benzyl phthalate during late pregnancy. Reprod. Toxicol. ; 16 (1):71-6. PubMed | |||||
| Ema et al. 1998 | Ema M, Miyawaki E, and Kawashima K. Further evaluation of developmental toxicity of di-n-butyl phthalate following administration during late pregnancy in rats. Toxicol. Lett. 1998; 98 (1-2):87-93. PubMed | |||||
| Ema et al. 2000 | Ema M, Miyawaki E, and Kawashima K. Critical period for adverse effects on development of reproductive system in male offspring of rats given di-n-butyl phthalate during late pregnancy. Toxicol. Lett. 2000; 111 (3):271-8. PubMed | |||||
| Fujii et al. 2005 | Fujii S et al. A two-generation reproductive toxicity study of diethyl phthalate (DEP) in rats. J Toxicol Sci 2005; 30 Spec No. ():97-116. PubMed | |||||
| Furr et al. 2014 | Furr JR et al. A short-term in vivo screen using fetal testosterone production, a key event in the phthalate adverse outcome pathway, to predict disruption of sexual differentiation. Toxicol. Sci. 2014; 140 (2):403-24. PubMed DOI | |||||
| Giribabu et al. 2014 | Giribabu N, Sainath SB, and Sreenivasula Reddy P. Prenatal di-n-butyl phthalate exposure alters reproductive functions at adulthood in male rats. Environ. Toxicol. 2014; 29 (5):534-44. PubMed DOI | |||||
| Gray et al. 2009 | Gray LE et al. Transgenerational effects of Di (2-ethylhexyl) phthalate in the male CRL:CD(SD) rat: added value of assessing multiple offspring per litter. Toxicol. Sci. 2009; 110 (2):411-25. PubMed DOI | |||||
| Hannas et al. 2011a | Hannas BR et al. Dipentyl phthalate dosing during sexual differentiation disrupts fetal testis function and postnatal development of the male Sprague-Dawley rat with greater relative potency than other phthalates. Toxicol. Sci. 2011; 120 (1):184-93. PubMed DOI | |||||
| Hannas et al. 2011b | Hannas BR et al. Dose-response assessment of fetal testosterone production and gene expression levels in rat testes following in utero exposure to diethylhexyl phthalate, diisobutyl phthalate, diisoheptyl phthalate, and diisononyl phthalate. Toxicol. Sci. 2011; 123 (1):206-16. PubMed DOI | |||||
| Hannas et al. 2012 | Hannas BR et al. Genomic biomarkers of phthalate-induced male reproductive developmental toxicity: a targeted RT-PCR array approach for defining relative potency. Toxicol. Sci. 2012; 125 (2):544-57. PubMed DOI | |||||
| Howdeshell et al. 2008 | Howdeshell KL et al. A mixture of five phthalate esters inhibits fetal testicular testosterone production in the sprague-dawley rat in a cumulative, dose-additive manner. Toxicol. Sci. 2008; 105 (1):153-65. PubMed DOI | |||||
| Jarfelt et al. 2005 | Jarfelt K et al. Antiandrogenic effects in male rats perinatally exposed to a mixture of di(2-ethylhexyl) phthalate and di(2-ethylhexyl) adipate. Reprod. Toxicol. ; 19 (4):505-15. PubMed | |||||
| Jiang et al. 2007 | Jiang J et al. Study on developmental abnormalities in hypospadiac male rats induced by maternal exposure to di-n-butyl phthalate (DBP). Toxicology 2007; 232 (3):286-93. PubMed | |||||
| Johnson et al. 2007 | Johnson KJ et al. Mapping gene expression changes in the fetal rat testis following acute dibutyl phthalate exposure defines a complex temporal cascade of responding cell types. Biol. Reprod. 2007; 77 (6):978-89. PubMed | |||||
| Johnson et al. 2011 | Johnson KJ et al. Species-specific dibutyl phthalate fetal testis endocrine disruption correlates with inhibition of SREBP2-dependent gene expression pathways. Toxicol. Sci. 2011; 120 (2):460-74. PubMed DOI | |||||
| Jones et al. 2015 | Jones S et al. In utero exposure to di-(2-ethylhexyl) phthalate induces testicular effects in neonatal rats that are antagonized by genistein cotreatment. Biol. Reprod. 2015; 93 (4):92. PubMed DOI | |||||
| Kim et al. 2010 | Kim TS et al. Effects of in utero exposure to DI(n-Butyl) phthalate on development of male reproductive tracts in Sprague-Dawley rats. J. Toxicol. Environ. Health Part A 2010; 73 (21-22):1544-59. PubMed DOI | |||||
| Klinefelter et al. 2012 | Klinefelter GR et al. Novel molecular targets associated with testicular dysgenesis induced by gestational exposure to diethylhexyl phthalate in the rat: a role for estradiol. Reproduction 2012; 144 (6):747-61. PubMed DOI | |||||
| Kuhl et al. 2007 | Kuhl AJ, Ross SM, and Gaido KW. CCAAT/enhancer binding protein beta, but not steroidogenic factor-1, modulates the phthalate-induced dysregulation of rat fetal testicular steroidogenesis. Endocrinology 2007; 148 (12):5851-64. PubMed | |||||
| L. Li et al. 2015 | Li L et al. Inutero exposure to diisononyl phthalate caused testicular dysgenesis of rat fetal testis. Toxicol. Lett. 2015; 232 (2):466-74. PubMed DOI | |||||
| Lee et al. 2004 | Lee KY et al. Diverse developmental toxicity of di-n-butyl phthalate in both sexes of rat offspring after maternal exposure during the period from late gestation through lactation. Toxicology 2004; 203 (1-3):221-38. PubMed | |||||
| Lehmann et al. 2004 | Lehmann KP et al. Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di (n-butyl) phthalate. Toxicol. Sci. 2004; 81 (1):60-8. PubMed | |||||
| Li et al. 2009 | Li Y et al. Neurobehavioral toxicity study of dibutyl phthalate on rats following in utero and lactational exposure. J Appl Toxicol 2009; 29 (7):603-11. PubMed DOI | |||||
| Li et al. 2013 | Li M et al. Dose-related effect by maternal exposure to di-(2-ethylhexyl) phthalate plasticizer on inducing hypospadiac male rats. Environ. Toxicol. Pharmacol. 2013; 35 (1):55-60. PubMed DOI | |||||
| Lin et al. 2008 | Lin H et al. Involvement of testicular growth factors in fetal Leydig cell aggregation after exposure to phthalate in utero. Proc. Natl. Acad. Sci. U.S.A. 2008; 105 (20):7218-22. PubMed DOI | |||||
| Lin et al. 2009 | Lin H et al. In utero and lactational exposures to diethylhexyl-phthalate affect two populations of Leydig cells in male Long-Evans rats. Biol. Reprod. 2009; 80 (5):882-8. PubMed DOI | |||||
| Liu et al. 2008 | Liu X et al. Di(2-ethylhexyl) phthalate (DEHP) increases transforming growth factor-beta1 expression in fetal mouse genital tubercles. J. Toxicol. Environ. Health Part A 2008; 71 (19):1289-94. PubMed DOI | |||||
| Macleod et al. 2010 | Macleod DJ et al. Androgen action in the masculinization programming window and development of male reproductive organs. Int. J. Androl. 2010; 33 (2):279-87. PubMed DOI | |||||
| Mahood et al. 2007 | Mahood IK et al. In utero exposure to di(n-butyl) phthalate and testicular dysgenesis: comparison of fetal and adult end points and their dose sensitivity. Environ. Health Perspect. 2007; 115 Suppl 1 ():55-61. PubMed DOI | |||||
| Martino-Andrade et al. 2009 | Martino-Andrade AJ et al. Coadministration of active phthalates results in disruption of foetal testicular function in rats. Int. J. Androl. 2009; 32 (6):704-12. PubMed DOI | |||||
| Masutomi et al. 2003 | Masutomi N et al. Impact of dietary exposure to methoxychlor, genistein, or diisononyl phthalate during the perinatal period on the development of the rat endocrine/reproductive systems in later life. Toxicology 2003; 192 (2-3):149-70. PubMed | |||||
| McKinnell et al. 2009 | McKinnell C et al. Effect of fetal or neonatal exposure to monobutyl phthalate (MBP) on testicular development and function in the marmoset. Hum. Reprod. 2009; 24 (9):2244-54. PubMed DOI | |||||
| Moore et al. 2001 | Moore RW et al. Abnormalities of sexual development in male rats with in utero and lactational exposure to the antiandrogenic plasticizer Di(2-ethylhexyl) phthalate. Environ. Health Perspect. 2001; 109 (3):229-37. PubMed |
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