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Available studies (70 found)

Short citationFull citationBioassayEpidemiologyEpi. meta-analysisIn vitroEcology
Adamsson et al. 2009 Adamsson A et al. Effects of maternal exposure to di-isononylphthalate (DINP) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) on steroidogenesis in the fetal rat testis and adrenal gland. Reprod. Toxicol. 2009; 28 (1):66-74. PubMed DOI
Ahmad et al. 2014 Ahmad R et al. Effects of in utero di-butyl phthalate and butyl benzyl phthalate exposure on offspring development and male reproduction of rat. Environ Sci Pollut Res Int 2014; 21 (4):3156-65. PubMed DOI
Andrade et al. 2006 Andrade AJ et al. A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): effects on androgenic status, developmental landmarks and testicular histology in male offspring rats. Toxicology 2006; 225 (1):64-74. PubMed
Ashby et al. 1997 Ashby J et al. Normal sexual development of rats exposed to butyl benzyl phthalate from conception to weaning. Regul. Toxicol. Pharmacol. 1997; 26 (1 Pt 1):102-18. PubMed
Aso et al. 2005 Aso S et al. A two-generation reproductive toxicity study of butyl benzyl phthalate in rats. J Toxicol Sci 2005; 30 Spec No. ():39-58. PubMed
Barlow et al. 2004 Barlow NJ, McIntyre BS, and Foster PM. Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to di(n-butyl) phthalate. Toxicol Pathol ; 32 (1):79-90. PubMed
Beverly et al. 2014 Beverly BE et al. Simvastatin and dipentyl phthalate lower ex vivo testicular testosterone production and exhibit additive effects on testicular testosterone and gene expression via distinct mechanistic pathways in the fetal rat. Toxicol. Sci. 2014; 141 (2):524-37. PubMed DOI
Boberg et al. 2011 Boberg J et al. Reproductive and behavioral effects of diisononyl phthalate (DINP) in perinatally exposed rats. Reprod. Toxicol. 2011; 31 (2):200-9. PubMed DOI
Borch et al. 2004 Borch J et al. Steroidogenesis in fetal male rats is reduced by DEHP and DINP, but endocrine effects of DEHP are not modulated by DEHA in fetal, prepubertal and adult male rats. Reprod. Toxicol. ; 18 (1):53-61. PubMed
Borch et al. 2006 Borch J et al. Mechanisms underlying the anti-androgenic effects of diethylhexyl phthalate in fetal rat testis. Toxicology 2006; 223 (1-2):144-55. PubMed
Christiansen et al. 2009 Christiansen S et al. Synergistic disruption of external male sex organ development by a mixture of four antiandrogens. Environ. Health Perspect. 2009; 117 (12):1839-46. PubMed DOI
Christiansen et al. 2010 Christiansen S et al. Low-dose perinatal exposure to di(2-ethylhexyl) phthalate induces anti-androgenic effects in male rats. Reprod. Toxicol. 2010; 30 (2):313-21. PubMed DOI
Clewell et al. 2009 Clewell RA et al. Kinetics of selected di-n-butyl phthalate metabolites and fetal testosterone following repeated and single administration in pregnant rats. Toxicology 2009; 255 (1-2):80-90. PubMed DOI
Clewell et al. 2013 Clewell RA et al. A dose response study to assess effects after dietary administration of diisononyl phthalate (DINP) in gestation and lactation on male rat sexual development. Reprod. Toxicol. 2013; 35 ():70-80. PubMed DOI
Culty et al. 2008 Culty M et al. In utero exposure to di-(2-ethylhexyl) phthalate exerts both short-term and long-lasting suppressive effects on testosterone production in the rat. Biol. Reprod. 2008; 78 (6):1018-28. PubMed DOI
Do et al. 2012 Do RP et al. Non-monotonic dose effects of in utero exposure to di(2-ethylhexyl) phthalate (DEHP) on testicular and serum testosterone and anogenital distance in male mouse fetuses. Reprod. Toxicol. 2012; 34 (4):614-21. PubMed DOI
Drake et al. 2009 Drake AJ et al. Glucocorticoids amplify dibutyl phthalate-induced disruption of testosterone production and male reproductive development. Endocrinology 2009; 150 (11):5055-64. PubMed DOI
Ema and Miyawaki 2002 Ema M and Miyawaki E. Effects on development of the reproductive system in male offspring of rats given butyl benzyl phthalate during late pregnancy. Reprod. Toxicol. ; 16 (1):71-6. PubMed
Ema et al. 1998 Ema M, Miyawaki E, and Kawashima K. Further evaluation of developmental toxicity of di-n-butyl phthalate following administration during late pregnancy in rats. Toxicol. Lett. 1998; 98 (1-2):87-93. PubMed
Ema et al. 2000 Ema M, Miyawaki E, and Kawashima K. Critical period for adverse effects on development of reproductive system in male offspring of rats given di-n-butyl phthalate during late pregnancy. Toxicol. Lett. 2000; 111 (3):271-8. PubMed
Fujii et al. 2005 Fujii S et al. A two-generation reproductive toxicity study of diethyl phthalate (DEP) in rats. J Toxicol Sci 2005; 30 Spec No. ():97-116. PubMed
Furr et al. 2014 Furr JR et al. A short-term in vivo screen using fetal testosterone production, a key event in the phthalate adverse outcome pathway, to predict disruption of sexual differentiation. Toxicol. Sci. 2014; 140 (2):403-24. PubMed DOI
Giribabu et al. 2014 Giribabu N, Sainath SB, and Sreenivasula Reddy P. Prenatal di-n-butyl phthalate exposure alters reproductive functions at adulthood in male rats. Environ. Toxicol. 2014; 29 (5):534-44. PubMed DOI
Gray et al. 2009 Gray LE et al. Transgenerational effects of Di (2-ethylhexyl) phthalate in the male CRL:CD(SD) rat: added value of assessing multiple offspring per litter. Toxicol. Sci. 2009; 110 (2):411-25. PubMed DOI
Hannas et al. 2011a Hannas BR et al. Dipentyl phthalate dosing during sexual differentiation disrupts fetal testis function and postnatal development of the male Sprague-Dawley rat with greater relative potency than other phthalates. Toxicol. Sci. 2011; 120 (1):184-93. PubMed DOI
Hannas et al. 2011b Hannas BR et al. Dose-response assessment of fetal testosterone production and gene expression levels in rat testes following in utero exposure to diethylhexyl phthalate, diisobutyl phthalate, diisoheptyl phthalate, and diisononyl phthalate. Toxicol. Sci. 2011; 123 (1):206-16. PubMed DOI
Hannas et al. 2012 Hannas BR et al. Genomic biomarkers of phthalate-induced male reproductive developmental toxicity: a targeted RT-PCR array approach for defining relative potency. Toxicol. Sci. 2012; 125 (2):544-57. PubMed DOI
Howdeshell et al. 2008 Howdeshell KL et al. A mixture of five phthalate esters inhibits fetal testicular testosterone production in the sprague-dawley rat in a cumulative, dose-additive manner. Toxicol. Sci. 2008; 105 (1):153-65. PubMed DOI
Jarfelt et al. 2005 Jarfelt K et al. Antiandrogenic effects in male rats perinatally exposed to a mixture of di(2-ethylhexyl) phthalate and di(2-ethylhexyl) adipate. Reprod. Toxicol. ; 19 (4):505-15. PubMed
Jiang et al. 2007 Jiang J et al. Study on developmental abnormalities in hypospadiac male rats induced by maternal exposure to di-n-butyl phthalate (DBP). Toxicology 2007; 232 (3):286-93. PubMed
Johnson et al. 2007 Johnson KJ et al. Mapping gene expression changes in the fetal rat testis following acute dibutyl phthalate exposure defines a complex temporal cascade of responding cell types. Biol. Reprod. 2007; 77 (6):978-89. PubMed
Johnson et al. 2011 Johnson KJ et al. Species-specific dibutyl phthalate fetal testis endocrine disruption correlates with inhibition of SREBP2-dependent gene expression pathways. Toxicol. Sci. 2011; 120 (2):460-74. PubMed DOI
Jones et al. 2015 Jones S et al. In utero exposure to di-(2-ethylhexyl) phthalate induces testicular effects in neonatal rats that are antagonized by genistein cotreatment. Biol. Reprod. 2015; 93 (4):92. PubMed DOI
Kim et al. 2010 Kim TS et al. Effects of in utero exposure to DI(n-Butyl) phthalate on development of male reproductive tracts in Sprague-Dawley rats. J. Toxicol. Environ. Health Part A 2010; 73 (21-22):1544-59. PubMed DOI
Klinefelter et al. 2012 Klinefelter GR et al. Novel molecular targets associated with testicular dysgenesis induced by gestational exposure to diethylhexyl phthalate in the rat: a role for estradiol. Reproduction 2012; 144 (6):747-61. PubMed DOI
Kuhl et al. 2007 Kuhl AJ, Ross SM, and Gaido KW. CCAAT/enhancer binding protein beta, but not steroidogenic factor-1, modulates the phthalate-induced dysregulation of rat fetal testicular steroidogenesis. Endocrinology 2007; 148 (12):5851-64. PubMed
L. Li et al. 2015 Li L et al. Inutero exposure to diisononyl phthalate caused testicular dysgenesis of rat fetal testis. Toxicol. Lett. 2015; 232 (2):466-74. PubMed DOI
Lee et al. 2004 Lee KY et al. Diverse developmental toxicity of di-n-butyl phthalate in both sexes of rat offspring after maternal exposure during the period from late gestation through lactation. Toxicology 2004; 203 (1-3):221-38. PubMed
Lehmann et al. 2004 Lehmann KP et al. Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di (n-butyl) phthalate. Toxicol. Sci. 2004; 81 (1):60-8. PubMed
Li et al. 2009 Li Y et al. Neurobehavioral toxicity study of dibutyl phthalate on rats following in utero and lactational exposure. J Appl Toxicol 2009; 29 (7):603-11. PubMed DOI
Li et al. 2013 Li M et al. Dose-related effect by maternal exposure to di-(2-ethylhexyl) phthalate plasticizer on inducing hypospadiac male rats. Environ. Toxicol. Pharmacol. 2013; 35 (1):55-60. PubMed DOI
Lin et al. 2008 Lin H et al. Involvement of testicular growth factors in fetal Leydig cell aggregation after exposure to phthalate in utero. Proc. Natl. Acad. Sci. U.S.A. 2008; 105 (20):7218-22. PubMed DOI
Lin et al. 2009 Lin H et al. In utero and lactational exposures to diethylhexyl-phthalate affect two populations of Leydig cells in male Long-Evans rats. Biol. Reprod. 2009; 80 (5):882-8. PubMed DOI
Liu et al. 2008 Liu X et al. Di(2-ethylhexyl) phthalate (DEHP) increases transforming growth factor-beta1 expression in fetal mouse genital tubercles. J. Toxicol. Environ. Health Part A 2008; 71 (19):1289-94. PubMed DOI
Macleod et al. 2010 Macleod DJ et al. Androgen action in the masculinization programming window and development of male reproductive organs. Int. J. Androl. 2010; 33 (2):279-87. PubMed DOI
Mahood et al. 2007 Mahood IK et al. In utero exposure to di(n-butyl) phthalate and testicular dysgenesis: comparison of fetal and adult end points and their dose sensitivity. Environ. Health Perspect. 2007; 115 Suppl 1 ():55-61. PubMed DOI
Martino-Andrade et al. 2009 Martino-Andrade AJ et al. Coadministration of active phthalates results in disruption of foetal testicular function in rats. Int. J. Androl. 2009; 32 (6):704-12. PubMed DOI
Masutomi et al. 2003 Masutomi N et al. Impact of dietary exposure to methoxychlor, genistein, or diisononyl phthalate during the perinatal period on the development of the rat endocrine/reproductive systems in later life. Toxicology 2003; 192 (2-3):149-70. PubMed
McKinnell et al. 2009 McKinnell C et al. Effect of fetal or neonatal exposure to monobutyl phthalate (MBP) on testicular development and function in the marmoset. Hum. Reprod. 2009; 24 (9):2244-54. PubMed DOI
Moore et al. 2001 Moore RW et al. Abnormalities of sexual development in male rats with in utero and lactational exposure to the antiandrogenic plasticizer Di(2-ethylhexyl) phthalate. Environ. Health Perspect. 2001; 109 (3):229-37. PubMed

Showing studies 1-50 of 70