HAWC is a modular, content management system designed to store, display, and synthesize multiple data sources for the purpose of producing human health assessments of chemicals. This online application documents the overall workflow of developing an assessment, from literature search and systematic review, to data extraction (human epidemiology, animal bioassay, and in vitro assay), dose-response analysis, and finally evidence synthesis and visualization.
HAWC is a collaboration of several individuals and organizations who create, maintain, and enhance the functionalities of this tool. The lead developer of the project is Andy Shapiro, who created the prototype in partial fulfillment of the requirements for the degree of Masters of Science in Public Health in the Department of Environmental Sciences and Engineering at the University of North Carolina at Chapel Hill under direction of Dr. Ivan Rusyn. Overall guidance on HAWC development is provided by a steering committee with representation from the National Toxicology Program at the National Institute of Environmental Health Sciences (NIEHS/NTP), Texas A&M University, and the National Center for Computational Toxicology of the Environmental Protection Agency (EPA/NCCT).
HAWC is open-source software under the permissive MIT license. It is free to create an account to use the software. It is also free to download, edit, and modify the source code. For more details, view the full license. Current version: 03abcf824...
MIT License Copyright (c) 2018 National Institute for Environmental Health Sciences, Texas A&M University, and University of North Carolina at Chapel Hill Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files (the "Software"), to deal in the Software without restriction, including without limitation the rights to use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of the Software, and to permit persons to whom the Software is furnished to do so, subject to the following conditions: The above copyright notice and this permission notice shall be included in all copies or substantial portions of the Software. THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE. In addition to the MIT License, the following notice is added: This license does not imply an endorsement of any product or service by the U.S. federal government or any of its organizations, units, or employees, Texas A&M University, or the University of North Carolina at Chapel Hill. The notice shall be included in all copies or substantial portions of the Software.
Want more details? Read our paper:
Shapiro AJ, Antoni S, Guyton KZ, Lunn RM, Loomis D, Rusyn I, Jahnke GD, Schwingl PJ, Mehta SS, Addington J, Guha N. Software Tools to Facilitate Systematic Review Used for Cancer Hazard Identification. Environ Health Perspect. 2018 Oct;126(10):104501. DOI: 10.1289/EHP4224
If you find HAWC useful in your work, a citation is always appreciated. To cite, either use the paper above, or the recommended citation below:
HAWC: Health Assessment Workplace Collaborative [Computer software]. (2013).
URL: https://hawcproject.org. [Month, year of date use].
Documentation for HAWC is available at https://hawc.readthedocs.io. Please note that this also includes detailed notes on the statistical methods used in this application.
The HAWC database is changing daily as users add more data to assessments. Below is a list of the current counts for different types of data captured in the database. Note that in most cases, these data are available in assessments which may not be publicly accessible (yet):
Last updated: Dec. 14, 2019, 9:04 p.m.
|Presentation title||Audience||Link (and format)|
|HAWCPROJECT.ORG: A content management system for human health assessments||2018 National Academy of Sciences: Strategies and Tools for Conducting Systematic Reviews of Mechanistic Data to Support Chemical Assessments||Poster|
|HAWC: current capabilities and uses at the US National Toxicology Program (NIH/NIEHS/NTP)||2015 National Toxicology Program (NTP) Board of Scientific Counselors||Slides|
|HAWC: A Modular Web-based Interface to Facilitate Development of Human Health Assessments of Chemicals||2014 Society of Toxicology (SOT)||Poster|
|HAWC presentation overview and tutorial of key functionality including literature search, animal bioassay data extraction, and BMD modeling.||2014 Webinar||
|HAWC: A Modular Web-based Interface to Facilitate Development of Human Health Assessments of Chemicals||2013 OpenTox USA||Poster|
|Web-based Benchmark Dose Modeling Module as a Prototype Component of an Informatics-based System for Human Health Assessments of Chemicals||2013 Society of Toxicology (SOT)||Poster|
This project is supported, in part, by funding from the following sources:
The contents of HAWC are solely the responsibility of the users and developers, and do not necessarily represent the official views of EPA, NIH, NTP, or WHO. Further, EPA, NIH, NTP, and WHO do not endorse the purchase or use of any commercial or open-source products or services that were used in the development of HAWC.