Experiment 1. Thirty-two dams were randomized into four groups dosed with either vehicle (peanut oil), 300 mg DEHP/kg bodyweight per day, 750 mg DINP/kg bodyweight per day, or with 300 mg DEHP/ kg bodyweight per day plus 750 mg DINP/kg bodyweight per day.\

Experiment 2. Forty-eight time-mated Wistar rats (Mol:WIST, SPF, Taconic M&B, Denmark) were housed in pairs and randomized into three groups with similar body weight distributions.

Method not stated.

Thirty-two dams wererandomized into four groups dosed with either vehi-

cle (peanut oil), 300 mg DEHP/kg bodyweight per day,

750 mg DINP/kg bodyweight per day, or with 300 mg DEHP/

kg bodyweight per day plus 750 mg DINP/kg bodyweight

per day.

Forty-eight time-mated Wis-tar rats (Mol:WIST, SPF, Taconic M&B, Denmark) were

housed in pairs and randomized into three groups with sim-

ilar body weight distributions. On GD 21, eight randomly selected dams per groupwere anesthetized in CO

2

/O

2

and decapitated, and fetuses

were removed and decapitated.

Eighty time-matedWistar rats were randomized into four groups receiving

either 0, 300 or 750 mg DEHP/kg bodyweight per day, or

750 mg DEHP/kg bodyweight per day in combination with

400 mg DEHA/kg bodyweight per day from GD 7 to PND

17. Three randomly selected males per litter from 10 litters

per group were sacrificed at PND 22, and further one or

two males per litter were sacrificed at PND 190.

But method of randomization not reported.

Name	Type	Comments
Developmental toxicity	Developmental	DEHP (Experiment 1)
Developmental toxicity	Developmental	DINP (Experiment 1)
Developmental toxicity	Developmental	DEHP (Experiment 2)

Borch et al. 2004

Risk of bias

Animal bioassay experiments

HAWC