The test substancewas dissolved in olive oil (Fujimi Pharmaceutical Co.,

Osaka, Japan, Lot number 016OAA), and administered

orally by gavage before mating for 10 weeks and then

during the mating period. Each animal received 5 mL/kg for seven days per week con-

taining doses of 0, 100, 200, and 400 mg/kg/day.

Authors stated the same vehicle and volume/BW was administered to animals in each group for the same amount of time. Animal husbandry across groups was not stated as identical, but it is assumed to be.

Aso et al. 2005

Risk of bias

Animal bioassay experiments

HAWC