Hypersensitivity - IgE

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Total IgE measured in cord blood with maternal PFOA and PFOS concentrations: 
  • Okada (2012) Cord IgE significant reduced for log10 cubic, linear and quadratic analyses for PFOA in female offspring, PFOA analyses for male offspring were not significant. PFOA exposure resulted in reduced cord IgE in combined male and female analysis as a result of affect on females. No analysis for PFOS was significant. 
  • Ashley-Martin (2015)  there was no association between maternal PFOA or PFOS and cord IgE in the Canadian MIREC cohort
Not on this graph - total IgE in cord blood analyzed by regression (beta) with maternal PFOA and PFOS concentrations: 
  • Wang (2011) maternal PFOA and PFOS were associated with increased cord IgE in Taiwan Birth Panel cohort that was only significant in boys in analyses separated by gender
Not on this graph - total IgE measured in children or mothers with current PFOA and PFOS concentrations: 
  • White (2011) reported PFOS-associated decrease in total IgE in nursing mothers in the MAMA study and wheeze in children up to age 3
  • Dong (2013) reported PFOA- and PFOS-associated increase in total IgE in asthmatic children age 10-15 in Taiwan (not in non-asthmatics)
DISPLAY NOTES
  • Black Line separate PFOA top and PFOS bottom
  • Red symbols are reported as statistically significant