Figure D19: Disease Resistance in Animal Studies (PFOA and PFOS)

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Disease Resistance Assays (PFOA and PFOS): 
PFOA:
  • No experimental mammalian PFOA data reported.
  • Smits (2013) data [green text] from quail. 
  • Note: Kannan (2006) report sea otters with clinical signs of disease had higher PFOA concentrations in liver (different type of analysis so not included on this graph).
  • Note: Kannan (2010) report PFOA concentrations in liver did not differ between populations of bats with white-nose syndrome and healthy reference populations (different type of analysis so not included on this graph).
PFOS:
  • Guruge 2009 reported PFOS-associated decreases in disease resistance to influenza A
    • There was no significant difference between groups in survival time
    • There was a significant, dose-dependent increase in mortality (p=0.014)
    • There high dose (0.025mg/kg/bw-day) had a significantly decreased survival rate (p=0.035)
    • Body weight was significantly decreased on day 30 in both PFOS treatment groups (p<0.05)
  • Note: Kannan (2006) report sea otters with clinical signs of disease had higher PFOS concentrations in liver (different type of analysis so not included on this graph).
  • Note: Kannan (2010) report PFOS concentrations in liver did not differ between populations of bats with white-nose syndrome and healthy reference populations (different type of analysis so not included on this graph).
DISPLAY NOTE
  • Black Line separates PFOA data from PFOS