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Figure D37: Autoimmunity incidence relative to cumulative PFOA (10-year lag)
Autoimmunity:
- Only 10-year lag data presented in this figure (similar results were found for unlagged and lagged exposure analyses)
- Steenland (2013) examined association between estimated cumulative PFOA exposure and incidence of autoimmune diseases with >50 validated cases (Crohn's disease, insulin-dependent diabetes, lupus, multiple sclerosis, rheumatoid arthritis, and ulcerative colitis) - only ulcerative colitis was significantly associated with PFOA
- p trend for 10-year lagged cumulative exposure p <0.0001 and ulcerative colitis
- p trend for unlagged cumulative exposure p <0.0001 and ulcerative colitis
- Steenland (2015) examined association between estimated cumulative PFOA exposure for workers with ulcerative colitis and rheumatoid arthritis
- p trend for 10-year lagged cumulative exposure p = 0.05 and ulcerative colitis
- p trend for unlagged cumulative exposure p = 0.05 and ulcerative colitis
- Orange Dashed Line separates different autoimmune diseases