Figure D08: Antigen-Specific IgM Antibody Response (PFOS)

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Antigen-specific IgM antibody response (PFOS):
  • Primary (after a single challenge) IgM antibody data.
  • Keil (2008) data [in blue] and Peden-Adams (2009) were exposed during development; all other data from adult exposures.
  • Peden-Adams (2009) data are from chickens; all other data are from mice.
  • Peden-Adams (2009) IgM + IgY data is measure of combined response with both antibodies and avian IgY is analogous to mammalian IgG. 
  • Vetvicka (2013), Qazi (2010b) and subset of Peden-Adams (2008) data [in orange] animals immunized with TNP and therefore represent T-cell independent responses; all other animals represent a T-cell dependent response and were immunized with SRBC.
  • Vetvicka (2013) ovalbumin-specific (OVA) antibody data not included. Study reported suppression of OVA-specific antibodies in female mice (20mg/kg PFOS via gavage for 3 weeks); however, exposure compared to positive control (OVA+Freund's adjuvant), not against vehicle control. Antibodies measured by ELISA -unknown if antibodies were IgM or IgG. 
DISPLAY NOTES
  • Black Lines separate antibody measurement methods: 1)ELISA to measure circulating antibody titres or levels in most studies from 2)PFC (plaque-forming cell) assay to count antibody secreting cells in a single study Yang (2002b) from 3)hemagglutination  or concentration at which antibodies cross link antigens
  • Red symbols are reported as statistically significant