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Figure D09: Antigen-Specific IgG Antibody Response (PFOS)
Antigen-specific IgG antibody response (PFOS):
- Antibody data include both primary (after a single challenge) and secondary (challenge and booster) IgG response.
- Antibody data presented as circulating antibody titres or levels (measured by ELISA) or hemagglutination.
- Peden-Adams (2009) data [in blue] are from chickens exposed during development; all other data from adult exposures.
- Peden-Adams (2009) IgM + IgY data is measure of combined agglutination response with both antibodies and avian IgY is analogous to mammalian IgG.
- Lefebvre (2008) data [green] are from rats; Peden-Adams (2009) data are from chickens; all other data from mice.
- Lefebvre (2008) animals were immunized with KLH; all other animals were immunized with SRBC or HRBC.
- Vetvicka (2013) ovalbumin-specific (OVA) antibody data not included. Study reported suppression of OVA-specific antibodies in female mice (20mg/kg PFOS via gavage for 3 weeks); however, exposure compared to positive control (OVA+Freund's adjuvant), not against vehicle control. Antibodies measured by ELISA -unknown if antibodies were IgM or IgG.
- DISPLAY NOTES
- Orange Line separates antibody data measuring IgG 1)primary response (after single challenge) from 2)secondary response (challenge + booster).
- Black Line separates antibody measurement methods: 1)ELISA to measure circulating antibody titres or levels in most studies from 2)hemagglutination or concentration at which antibodies cross link antigens
- Red symbols are reported as statistically significant