Supplemental Figure 08. Estrogen Receptor Reporter Gene Assays

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Antagonism assays are shown in blue text. Agonism assays are shown in black text. Solid lines separate different chemicals.


Not shown in this figure:

  • Coleman et al. 2003 presented relative gene induction as ratio of AC50 values compared to E2 (100%)
  • 4,4-Bisphenol F 0.00053% of E2
  • Bisphenol A 0.00275% of E2
  • Bisphenol AF 0.00161% of E2
  • Bisphenol AP 0.00009% of E2
  • Bisphenol B 0.00052% of E2
  • Bisphenol C 0.00049% of E2
  • Bisphenol E 0.00071% of E2
  • Bisphenol Z 0.00069% of E2
  • TMBPA 0.00016% of E2
  • Kolle et al. 2010 presented qualitative results only (+ or - activity in a screening assay)
  • 4,4-Bisphenol F + in agonist assay, - in antagonist assay, but cytotoxicity was noted
  • Bisphenol S - in agonist assay, slightly positive in antagonist assay
  • Bisphenol Z + in agonist assay, - in antagonist assay, but cytotoxicity was noted
  • Rivas et al. 2002 presented luciferase induction as a ratio of maximal inductive effect compared to E2 (100%)
  • Bisphenol AF 90% of E2
  • Bisphenol B 134.28% of E2
  • Bisphenol E 127.85% of E2
  • Yoshihara et al. 2001 showed that the estrogenicity of BPB was increased in the presence of complete S9 compared to denatured S9