Supplemental Figure 07. Estrogen Receptor Cell Proliferation Assays

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Assays run in antagonist mode are shown in blue text, assays run in agonist mode are shown in black text. It is noted under "endpoint description" if the assay was carried out in the presence of ICI, E2, or Tamoxifen (TAM). Solid lines separate different chemicals.


Note: In Delfosee et al. 2012the authors expected a decrease in proliferation in HeLa cells stably transfected with ER, as the same effect is observed with E2 treatment.


Not shown in this figure:

  • Coleman et al. 2003 presented relative proliferative effect as ratio of AC50 values compared to E2 (100%)
  • 4,4-Bisphenol F 0.001% of E2
  • Bisphenol A 0.002% of E2
  • Bisphenol AF 0.0089% of E2
  • Bisphenol AP 0.0006% of E2
  • Bisphenol B 0.0018% of E2
  • Bisphenol C 0.0016% of E2
  • Bisphenol E 0.0015% of E2
  • Bisphenol Z 0.0047% of E2
  • TMBPA 0.0015% of E2
  • Perez et al. 1998presented relative proliferative effect compared to E2 (100%)
  • Bisphenol AF 78.94% of E2
  • Bisphenol B 85.96% of E2
  • Bisphenol E 92.98% of E2
  • Vinas and Watson 2013data for BPS in Figure 5a is the same data as Vinas et al. 2013 Figure 4 and is therefore not shown.