Available visualizations
| Visual | Type | Created | Modified |
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test
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animal bioassay endpoint crossview | 2016-09-15 | 2016-09-15 |
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Antigen-specific IgM antibody response (PFOS): Primary (after a single challenge) IgM antibody data.Keil (2008) data [in blue] and Peden-Adams (2009) were exposed during development; all other …
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Data pivot (animal bioassay) | 2016-07-14 | 2020-04-01 |
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Autoimmunity : Steenland (2013) examined association between estimated cumulative PFOA exposure and incidence of autoimmune diseases with >50 validated cases (Crohn's disease, insulin-dependent …
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Data pivot (epidemiology) | 2016-01-03 | 2020-04-01 |
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Autoimmunity: ulcerative colitis Steenland (2013) examined association between estimated cumulative PFOA exposure and incidence of autoimmune diseases with >50 validated cases (Crohn's …
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Data pivot (epidemiology) | 2016-02-26 | 2020-04-01 |
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Cell phenotyping B cells (CD19 or B220):
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Data pivot (animal bioassay) | 2016-10-03 | 2020-04-01 |
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Cell phenotyping B cells (CD19 or B220):
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Data pivot (animal bioassay) | 2015-11-29 | 2020-04-01 |
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Cell phenotyping Macrophages and antigen presenting cells (F4/80+, MHC-II+, and CD40+)
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Data pivot (animal bioassay) | 2016-03-16 | 2020-04-01 |
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Cell phenotyping NK cells (CD16, NK 1.1):
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Data pivot (animal bioassay) | 2015-11-30 | 2020-04-01 |
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Cell phenotyping CD4 (PFOA): Note: Yang 2006 not included because cell phenotyping data appear to be previously reported in Yang 2000.
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Data pivot (animal bioassay) | 2015-09-02 | 2020-04-01 |
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Cell phenotyping CD8 (PFOA): Note: Yang 2006 not included because cell phenotyping data appear to be previously reported in Yang 2000.
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Data pivot (animal bioassay) | 2015-11-29 | 2020-04-01 |
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Cell phenotyping DN CD4- and CD8-
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Data pivot (animal bioassay) | 2015-11-29 | 2020-04-01 |
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Cell phenotyping DP CD4+ and CD8+
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Data pivot (animal bioassay) | 2015-11-29 | 2020-04-01 |
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Spleen Cellularity (total cell number) (PFOA): All data presented as % control of total spleen cell number.
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Data pivot (animal bioassay) | 2015-08-11 | 2020-04-01 |
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Spleen Cellularity (total cell number) (PFOA): All data presented as % control of total spleen cell number.Keil (2008) data [in blue] are from …
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Data pivot (animal bioassay) | 2015-08-11 | 2020-04-01 |
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Thymus Cellularity (total cell number) (PFOA): All data presented as % control of total thymus cell number.
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Data pivot (animal bioassay) | 2015-08-11 | 2020-04-01 |
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Thymus Cellularity (total cell number) (PFOS): All data presented as % control of total thymus cell number.
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Data pivot (animal bioassay) | 2015-08-11 | 2020-04-01 |
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Immunoglobulin levels: Total IgGNote: Wantanabe (2010) measured serum IgG in wild pigs at a reference and dumping site with PFOS and …
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Data pivot (animal bioassay) | 2015-12-08 | 2020-04-01 |
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Immunoglobulin levels: Total IgM
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Data pivot (animal bioassay) | 2015-12-08 | 2020-04-01 |
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Cytokine - IFN gamma (PFOA or PFOS): Note: Ryu reported increased relative mRNA expression for IFN-gamma in lung tissue of mice exposed …
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Data pivot (animal bioassay) | 2015-07-29 | 2020-04-01 |
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Cytokine - IL1 (PFOA or PFOS): Alsarra 2006 reported no change in IL-1 beta after exposure of male rats to 100mg/kg PFOA for …
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Data pivot (animal bioassay) | 2015-09-01 | 2020-04-01 |
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Cytokine - IL10 (PFOA or PFOS): Note: no PFOA studies located with data on IL-10
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Data pivot (animal bioassay) | 2015-08-31 | 2020-04-01 |
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Cytokine - IL2 (PFOA or PFOS): Note: no PFOA studies located with data on IL-2
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Data pivot (animal bioassay) | 2015-08-31 | 2020-04-01 |
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Cytokine - IL4 (PFOA or PFOS):
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Data pivot (animal bioassay) | 2015-08-12 | 2020-04-01 |
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Cytokine - IL5 (PFOA or PFOS): Note: no PFOA studies located with data on IL-5
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Data pivot (animal bioassay) | 2015-11-29 | 2020-04-01 |
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Cytokine - IL6 (PFOA or PFOS):
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Data pivot (animal bioassay) | 2015-08-31 | 2020-04-01 |
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Cytokine - TNF-alpha (PFOA and PFOS): Note: Alsarra 2006 reported no change in IL-1 beta after exposure of male rats to 100mg/kg PFOA for …
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Data pivot (animal bioassay) | 2015-08-11 | 2020-04-01 |
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Delayed-Type Hypersensitivity [DTH] (PFOA and PFOS): PFOA:Note: DeWitt (2008) report no effect of PFOA exposure (up to 30 mg/kg via gavage) for 10 days on …
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Data pivot (animal bioassay) | 2015-07-24 | 2020-04-01 |
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Risk of Bias Heatmap for all epidemiology studies.Note: White et al. 2011 not assessed for risk of bias because it was …
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risk of bias heatmap | 2015-12-03 | 2020-08-25 |
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Animal Risk of Bias visualization showing all studies.
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risk of bias heatmap | 2015-06-23 | 2020-08-25 |
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Wildlife studies
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risk of bias heatmap | 2016-03-13 | 2020-08-25 |
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All in-vitro risk of bias
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risk of bias heatmap | 2015-12-02 | 2020-08-25 |
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Vaccine-specific antibody response relative to maternal PFOA and PFOS presented as standardized regression beta: Granum (2013) - cohort tested association between maternal PFOA or PFOS …
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Data pivot (epidemiology) | 2015-11-02 | 2020-04-01 |
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Vaccine-specific antibody response for maternal exposure presented as estimated difference per 2-fold increase PFOA and PFOS concentration: Grandjean (2012) - cohort tested association …
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Data pivot (epidemiology) | 2015-12-19 | 2020-04-01 |
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Vaccine-specific antibody response for child exposure presented as estimated difference per 2-fold increase PFOA and PFOS concentration: Grandjean (2012) - cohort tested association …
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Data pivot (epidemiology) | 2015-12-19 | 2020-04-01 |
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Vaccine-specific antibody response as change antibody concentration post vaccination in adults presented as standardized regression beta (PFOA and PFOS): Looker (2014) - cohort tested association between …
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Data pivot (epidemiology) | 2015-11-29 | 2020-04-01 |
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Vaccine-specific antibody response in adults presented as percent change antibody concentration post vaccination (PFOA and PFOS): These studies reported antibody response as estimated …
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Data pivot (epidemiology) | 2015-11-24 | 2020-04-01 |
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Antigen-specific IgM antibody response (PFOA): All data are primary (after a single challenge) IgM antibody data.Hu (2010) data [in blue] are from mice exposed during …
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Data pivot (animal bioassay) | 2015-07-21 | 2020-04-01 |
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Antigen-specific IgG antibody response (PFOA): Smits (2013) data [green] are from birds (avian IgY is analogous to mammalian IgG); all …
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Data pivot (animal bioassay) | 2015-07-21 | 2020-04-01 |
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Antigen-specific IgM antibody response (PFOS): Primary (after a single challenge) IgM antibody data.Keil (2008) data [in blue] and Peden-Adams (2009) were exposed during development; all other …
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Data pivot (animal bioassay) | 2015-07-21 | 2020-04-01 |
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Antigen-specific IgG antibody response (PFOS): Antibody data include both primary (after a single challenge) and secondary (challenge and booster) IgG response. Antibody data …
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Data pivot (animal bioassay) | 2015-07-23 | 2020-04-01 |
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Note: Morgensen (2015) reports a re-analysis of the Granjean (2012) study and therefore was not included.
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risk of bias barchart | 2015-10-26 | 2020-08-25 |
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Note: Morgensen (2015) reports a re-analysis of the Grandjean (2012) study and therefore was not included.
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risk of bias heatmap | 2015-10-20 | 2020-08-25 |
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PFOA: risk of bias summary: Antibody response
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risk of bias barchart | 2015-09-15 | 2020-08-25 |
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PFOA risk of bias Heatmap: antibody response
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risk of bias heatmap | 2015-07-09 | 2020-08-25 |
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PFOS: risk of bias summary: antibody response
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risk of bias barchart | 2015-11-24 | 2020-08-25 |
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PFOS: risk of bias heatmap: Antibody response
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risk of bias heatmap | 2015-10-28 | 2020-08-25 |
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Infectious disease outcomes analyzed as odds ratio (PFOA and PFOS): Looker (2014) - cohort tested association between PFOA or PFOS and antibody …
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Data pivot (epidemiology) | 2015-12-21 | 2020-04-01 |
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Infectious disease - Granum 2013 study - episodes of common cold and gastroenteritis with maternal PFOA and PFOS: Granum (2013) prospective birth cohort in Norway in children …
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Data pivot (epidemiology) | 2016-02-28 | 2020-04-01 |
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Infectious disease outcomes analyzed as poisson regression Fei 2010 infectious disease relating to hospitalization in children 0-10 years of ageNot on …
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Data pivot (epidemiology) | 2016-01-06 | 2020-04-01 |
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Disease Resistance Assays (PFOA and PFOS): PFOA:No experimental mammalian PFOA data reported.Smits (2013) data [green text] from quail. Note: Kannan (2006) report sea otters with …
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Data pivot (animal bioassay) | 2015-12-21 | 2020-04-01 |
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Risk of Bias for human studies of infectious disease
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risk of bias barchart | 2015-12-22 | 2020-08-25 |
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Risk of Bias Heatmap
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risk of bias heatmap | 2015-12-22 | 2020-08-25 |
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PFOA and PFOS Risk of bias summary: Disease resistance. Note that Smits 2013 and Guruge 2009 are experimental exposures studies Kannan …
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risk of bias heatmap | 2016-03-02 | 2020-08-25 |
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Natural killer (NK) cell activityNK cell activity presented as either % activity (cytotoxicity of YAC-1 target cells) or lytic units. Note: …
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Data pivot (animal bioassay) | 2015-07-23 | 2020-04-01 |
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IN VITRO exposure: Natural Killer (NK) cell activity (PFOA or PFOS):
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Data pivot (in vitro) | 2015-12-20 | 2020-04-01 |
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PFOS: risk of bias summary: NK cell activity
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risk of bias barchart | 2015-11-28 | 2020-08-25 |
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PFOS risk of bias Heatmap: NK cell activity
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risk of bias heatmap | 2015-11-28 | 2020-08-25 |
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Asthma reported in children with current PFOA concentrations: Stein (2015) children from NHANES 2005-2006Humblet (2014) children from NHANES 1999-2000 and 2003-2008Dong (2013) case control …
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Data pivot (epidemiology) | 2016-03-07 | 2020-04-01 |
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Asthma reported in children with current PFOS concentrations: Stein (2015) children from NHANES 2005-2006Humblet (2014) children from NHANES 1999-2000 and 2003-2008Dong (2013) case control …
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Data pivot (epidemiology) | 2016-03-07 | 2020-04-01 |
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Airway responseFairley (2007) reported increased AUC for airway hyperreactivity to OVA with dermal PFOA exposureRyu (2014) tested multiple airway measures …
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Data pivot (animal bioassay) | 2015-12-31 | 2020-04-01 |
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Antigen-specific IgE responseFairley (2007) directly tested hypersensitivity response following 4-day dermal exposure to PFOS, including several measures of OVA-induced hypersensitivity. OVA-specific …
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Data pivot (animal bioassay) | 2015-12-08 | 2020-04-01 |
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Immunoglobulin levels: Total IgENote: Wantanabe (2010) measured serum IgE in wild pigs at a reference and dumping site with PFOS and …
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Data pivot (animal bioassay) | 2015-12-08 | 2020-04-01 |
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Hypersensitivity - Asthma in children with current PFOA and PFOS levels
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risk of bias barchart | 2016-03-09 | 2020-08-25 |
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Hypersensitivity - Asthma in children with current PFOA and PFOS levels
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risk of bias heatmap | 2016-03-09 | 2020-08-25 |
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Hypersensitivity studies
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risk of bias heatmap | 2016-01-03 | 2020-08-25 |
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Risk of bias summary: Hypersensitivity studies
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risk of bias barchart | 2015-12-31 | 2020-08-25 |
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Risk of bias Heatmap: hypersensitivity studiesRyu (2014) is a 12+ week dietary exposure study of PFOA and PFOS and airway …
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risk of bias heatmap | 2015-12-31 | 2020-08-25 |
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Autoimmunity: Only 10-year lag data presented in this figure (similar results were found for unlagged and lagged exposure analyses)Steenland (2013) examined …
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Data pivot (epidemiology) | 2016-02-26 | 2020-04-01 |
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Autoimmunity
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risk of bias barchart | 2016-01-03 | 2020-08-25 |
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Autoimmunity studies - only for PFOA exposure and only for ulcerative colitis
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risk of bias heatmap | 2016-01-03 | 2020-08-25 |
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Asthma reported in children with current PFOA and PFOS concentrations: Stein (2015) children from NHANES 2005-2006Humblet (2014) children from NHANES 1999-2000 and 2003-2008Dong (2013) …
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Data pivot (epidemiology) | 2016-01-02 | 2020-04-01 |
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Total IgE measured in cord blood with maternal PFOA and PFOS concentrations: Okada (2012) Cord IgE significant reduced for log10 cubic, linear and quadratic …
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Data pivot (epidemiology) | 2016-01-06 | 2020-04-01 |
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Wheeze measured in children with current PFOA and PFOS concentrations: Stein (2015) children from NHANES 2005-2006Humblet (2014) children from NHANES 1999-2000 and 2003-2008Wheeze measured in …
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Data pivot (epidemiology) | 2016-01-02 | 2020-04-01 |
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IN VITRO exposure: Cell viability (PFOA or PFOS):
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Data pivot (in vitro) | 2016-03-15 | 2020-04-01 |
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IN VITRO exposure: Cytokine production - IFN gamma (PFOA or PFOS):
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Data pivot (in vitro) | 2015-12-20 | 2020-04-01 |
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IN VITRO exposure: Cytokine production - IL10 (PFOA or PFOS):
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Data pivot (in vitro) | 2015-12-20 | 2020-04-01 |
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IN VITRO exposure: Cytokine production - IL4 (PFOA or PFOS):
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Data pivot (in vitro) | 2015-12-20 | 2020-04-01 |
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IN VITRO exposure: Cytokine production - IL6 (PFOA or PFOS):
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Data pivot (in vitro) | 2015-12-20 | 2020-04-01 |
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IN VITRO exposure: Cytokine production - IL6 (PFOA or PFOS):
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Data pivot (in vitro) | 2015-12-20 | 2020-04-01 |
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IN VITRO exposure: Cytokine production - TNF-alpha(PFOA or PFOS):
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Data pivot (in vitro) | 2015-12-20 | 2020-04-01 |
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IN VITRO exposure: Lymphocyte mitogen-induced proliferation (ConA) (PFOA or PFOS):
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Data pivot (in vitro) | 2015-12-07 | 2020-04-01 |
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IN VITRO exposure: Lymphocyte mitogen-induced proliferation (LPS) (PFOA or PFOS):
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Data pivot (in vitro) | 2015-12-20 | 2020-04-01 |
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Infectious disease - otitis media (PFOA and PFOS): Okada (2012) prospective cohort in Sapporo Japan of children at 18 months of ageGranum …
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Data pivot (epidemiology) | 2015-12-21 | 2020-04-01 |
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Lymphocyte mitogen-induced proliferation (ConA) (PFOA or PFOS): Note: Peden-Adams (2009) reported no effect of PFOS (1-4.6mg/kg) in ovo on chickens on ConA …
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Data pivot (animal bioassay) | 2015-09-01 | 2020-04-01 |
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Lymphocyte mitogen-induced proliferation (LPS) (PFOA or PFOS): Note: Peden-Adams (2009) reported no effect of PFOS (1-4.6mg/kg) in ovo on chickens on LPS …
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Data pivot (animal bioassay) | 2015-09-02 | 2020-04-01 |
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Neutrophil Phagocytosis:Vetvicka (2013) tested phagocytosis by peripheral blood neutrophils in female mice Moncyte or Granulocyte Phagocytosis:Note: Fair (2013) tested phagocytosis of Staphylococcus …
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Data pivot (animal bioassay) | 2015-07-27 | 2020-04-01 |
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Hypersensitivity
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risk of bias barchart | 2016-01-03 | 2020-08-25 |
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PFOS risk of bias Heatmap: NK cell activity. Only one study Vetvicka (2013)
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risk of bias heatmap | 2016-03-02 | 2020-08-25 |
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Spleen weight (PFOA): All data presented as % control of relative spleen weight (spleen/body weight x 100).Data from mice (black text) and rats …
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Data pivot (animal bioassay) | 2015-07-29 | 2020-04-01 |
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Spleen weight (PFOS): All data presented as % control of relative spleen weight (spleen/body weight x 100).Data from mice (black text) and rats …
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Data pivot (animal bioassay) | 2015-08-06 | 2020-04-01 |
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Spleen weight (PFOS): All data presented as absolute spleen weightData from mice (black text) and rats (green text).Keil (2008) data [in blue] are …
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Data pivot (animal bioassay) | 2015-12-20 | 2020-04-01 |
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Antibody responses
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animal bioassay endpoint crossview | 2015-07-24 | 2016-04-04 |
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Vaccine-specific antibody response for child exposure presented as estimated difference per 2-fold increase PFOA and PFOS concentration: Grandjean (2012) - cohort tested association …
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Data pivot (epidemiology) | 2016-05-25 | 2020-04-01 |
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Thymus weight (PFOA): All data presented as % control of relative thymus weight (thymus/body weight x 100).Data from mice (black text) and rats …
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Data pivot (animal bioassay) | 2015-07-27 | 2020-04-01 |
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Thymus weight (PFOS): All data presented as % control of relative thymus weight (thymus/body weight x 100).Data from mice (black text) and rats …
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Data pivot (animal bioassay) | 2015-07-29 | 2020-04-01 |
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Thymus weight (PFOS): All data presented as absolute thymus weightData from mice (black text) and rats (green text).Keil (2008) data [in blue] are …
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Data pivot (animal bioassay) | 2015-12-20 | 2020-04-01 |
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Vaccine-specific antibody response for child exposure presented as estimated difference per 2-fold increase PFOA and PFOS concentration: Grandjean (2012) - cohort tested association …
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Data pivot (epidemiology) | 2016-07-14 | 2020-04-01 |
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Vaccine-specific antibody response for child exposure presented as estimated difference per 2-fold increase PFOA and PFOS concentration: Grandjean (2012) - cohort tested association …
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Data pivot (epidemiology) | 2016-07-14 | 2020-04-01 |
98 visuals found.