Gimenez-Bastida 2015
Data type(s) | In vitro |
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Full citation | Gimenez-Bastida JA, Surma M, Zielinski H. 2015. In vitro evaluation of the cytotoxicity and modulation of mechanisms associated with inflammation induced by perfluorooctanesulfonate and perfluorooctanoic acid in human colon myofibroblasts CCD-18Co. Toxicology In Vitro 29(7): 1683-1691 |
Abstract | Perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA) are the most notable members of an emerging class of persistent organic pollutants (POPs), poly- and perfluoroalkyl acids (PFASs). In this study, the CCD-18Co myofibroblasts were selected as a cell model to investigate the cytotoxic effects of PFOS and PFOA. The aim was to perform an in vitro evaluation of the ability of these compounds to induce cytotoxicity and modulate mechanisms associated with inflammation as measured by (i) colon fibroblasts viability, (ii) colon fibroblasts proliferation, and (iii) IL-6 production. The data provided in this study suggest that PFOS and PFOA can have cytotoxic potential and modulate processes associated with intestinal inflammation such as myofibroblasts proliferation and IL-6 production at concentrations similar to those detected in vivo. Our results also highlight the influence of culture serum concentration in cytotoxic in vitro studies, which should be considered in future toxicity studies involving PFOS and PFOA. The results contribute to a better knowledge of the effects of PFOS and PFOA in human cells, a phenomenon still not fully examined. |
Reference hyperlink | |
Literature review tags | Mechanistic Study |
COI reported | Authors report they have no COI |
Funding source | Department of Chemistry and Biodynamics of Food of the Institute of Animal Reproduction of the Polish Academy of Sciences in Olsztyn, Poland |
Study identifier | (Gimenez-Bastida 2015) |
Author contacted? | true |
Author contact details | Author was contacted on April 21, 2016 related to questions for clarity in risk of bias evaluation. Author responded on April 27, 2016. |
Summary/extraction comments | Data extracted:
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Risk of bias
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