Ahuja 2009
| Data type(s) | In vitro |
|---|---|
| Full citation | Ahuja V, Eisenbltter M, Ignatius R, and Stahlmann R. 2009. Ammonium perfluorooctanoate substantially alters phenotype and cytokine secretion of human monocyte-derived dendritic cells in vitro. Immunopharm Immunot 31(4): 641-646. |
| Abstract | Perfluoroalkyl carboxylic acids (PFCA) are commercially used for their surfactant properties combined with chemical and thermal stability. Differentiation of peripheral monocytes to immature dendritic cells (DCs) in the presence of the PFCA, ammonium perfluorooctanoate (APFO, 200 microM) led to a considerably increased expression of CD86 and HLA-DR on immature DCs. However, these phenotypic changes were not reflected by an increased T cell-stimulatory capacity of the cells. Notably, activated, fully mature APFO-treated DCs secreted significantly less IL-12 and IL-10 than control cells. Thus, APFO at non-cytotoxic concentration affects the phenotype and cytokine secretion of human DCs. |
| Reference hyperlink | |
| Literature review tags | Mechanistic Study |
| COI reported | Authors report they have no COI |
| Funding source | not reported |
| Study identifier | {Ahuja, 2009#20} |
| Author contacted? | true |
| Author contact details | Author was contacted in April 2015 to obtain information for RoB assessment. No response was received to email request for clarification. |
| Summary/extraction comments | Data extracted:
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