Lin 2011
| Data type(s) | Epidemiology |
|---|---|
| Full citation | Lin CY, Wen LL, Lin LY, Wen TW, Lien GW, Chen CY, Hsu SH, Chien KL, Sung FC, Chen PC, and Su TC. 2011. Associations between levels of serum perfluorinated chemicals and adiponectin in a young hypertension cohort in Taiwan. Environ Sci Technol 45(24): 10691-10698. |
| Abstract | In animals, perfluorinated chemicals (PFCs), specifically perfluorooctanoic acid (PFOA) and perfluorooctane sulfate (PFOS), function as peroxisome proliferator-activated receptor (PPAR) alpha agonists. However, the relevance of animal (primarily rodent) data to humans is unresolved. While plasma adiponectin level is very responsive to PPAR gamma agonist drugs, it has not been determined whether adiponectin level is related to serum PFCs concentrations. In the present study, 287 subjects (12-30 years of age) were recruited to determine the relationship between serum level of PFCs and serum level of adiponectin. The results showed males had higher serum PFOS concentrations than females and that those with metabolic syndrome had lower serum PFOA than controls. Besides, it showed regional elevations of the perfluoroundecanoic acid (PFUA) (median concentration: 7.11 ng/mL) in the study subjects. No relationship of PFOA, PFOS, PFUA, and the sum of all four PFCs was found to glucose homeostasis, adiponectin level, lipid profile, and inflammatory markers. The median and the range of perfluorononanoic acid (PFNA) concentration (in ng/mL; for four categories corresponding to the <50, 50-74, 75-89, and ≥90th percentiles) were 0.38 (0.38-1.68), 3.22 (1.73-4.65), 5.85 (4.75-8.29), 10.56 (8.40-25.40), respectively. After controlling for confounding factors, multiple linear regression analysis revealed that the mean natural log-transformed level of adiponectin increased significantly across categories of PFNA (in ng/mL; 8.78, 8.73, 9.06, 9.36; P for trend = 0.010 in the full model). In conclusion, higher serum PFNA concentration is associated with elevated serum adiponectin concentration. |
| Reference hyperlink | |
| Literature review tags | Human Study |
| COI reported | Authors report they have no COI |
| Funding source | grants from the National Health Research Institute of Taiwan (NHRI-EX97-9721PC, EX97-9821PC, and X97-9921PC) and (NHRI-EX95-9531PI, EX95-9631PI, and EX95-9731PI) and from the National Science Council of Taiwan (99-2314-B-385-001-MY3) |
| Study identifier | (Lin 2011) |
| Author contacted? | false |
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