Innes 2011
| Data type(s) | Epidemiology |
|---|---|
| Full citation | Innes KE, Ducatman AM, Luster MI, and Shankar A. 2011. Association of osteoarthritis with serum levels of the environmental contaminants perfluorooctanoate and perfluorooctane sulfonate in a large Appalachian population. Am J Epidemiol 174(4): 440-450. |
| Abstract | Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are persistent environmental contaminants that affect metabolic regulation, inflammation, and other factors implicated in the pathogenesis of osteoarthritis (OA). However, the link between these compounds and OA remains unknown. In this study, the authors investigated the association of OA with PFOA and PFOS in a population of 49,432 adults from 6 PFOA-contaminated water districts in the mid-Ohio Valley (2005-2006). Participants completed a comprehensive health survey; serum levels of PFOA, PFOS, and a range of other blood markers were also measured. Medical history, including physician diagnosis of osteoarthritis, was assessed via self-report. Analyses included adjustment for demographic and lifestyle characteristics, body mass index, and other potential confounders. Reported OA showed a significant positive association with PFOA serum levels (for highest quartile of PFOA vs. lowest, adjusted odds ratio = 1.3, 95% confidence interval: 1.2, 1.5; P-trend = 0.00001) and a significant inverse association with PFOS (for highest quartile vs. lowest, adjusted odds ratio = 0.8, 95% confidence interval: 0.7, 0.9; P-trend = 0.00005). The relation between PFOA and OA was significantly stronger in younger and nonobese adults. Although the cross-sectional nature of this large, population-based study limits causal inference, the observed strong, divergent associations of reported OA with PFOA and PFOS may have important public health and etiologic implications and warrant further investigation. |
| Reference hyperlink | |
| Literature review tags | Human Study |
| COI reported | Authors report they have no COI |
| Funding source | contract with Brookmar, Inc, by the Mitchell M. benedict and Helen L. Benedict Endowment fund, and by NIH National Center for Complementary and Alternative Medicine and the Office of Research on Women's Health (grant 1 K01 AT004108 |
| Study identifier | (Innes 2011) |
| Author contacted? | true |
| Author contact details | CRP? Was it different by PFOA exposure? |
| Summary/extraction comments | Data extracted:
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