Vetvicka 2013

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Animal bioassay experiments

NameTypeComments
Single dose-level Short-term (1-30 days)
PFOA: Female BALB/c mice (8-wk-old) were purchased from the Jackson Laboratory (Bar Harbor, ME). All mice were housed in a sterile animal facility that was maintained at 22 °C and at a 35 % relative humidity, with a 12-hr light/- dark cycle. All mice had ad libitum access to standard mouse chow and filtered water throughout the studies. All mice were allowed to accli- mate for a minimum of 10 day prior to any exposure being performed. All mice were weighed prior to the first dosing and again daily to assure that dosing volumes were constant over the course of the treatments. All animal work was done according to a University of Louisville IACUC protocol and with the approval of that committee IACUC #04050.
Single dose-level Ab Short-term (1-30 days) PFOA: Female BALB/c mice (8-wk-old) were purchased from the Jackson Laboratory (Bar Harbor, ME). All mice were housed in a sterile animal facility that was maintained at 22 °C and at a 35 % relative humidity, with a 12-hr light/- dark cycle. All mice had ad libitum access to standard mouse chow and filtered water throughout the studies. All mice were allowed to accli- mate for a minimum of 10 day prior to any exposure being performed. All mice were weighed prior to the first dosing and again daily to assure that dosing volumes were constant over the course of the treatments. All animal work was done according to a University of Louisville IACUC protocol and with the approval of that committee IACUC #04050.
Single dose-level Short-term (1-30 days) PFOS: Female BALB/c mice (8-wk-old) were purchased from the Jackson Laboratory (Bar Harbor, ME). All mice were housed in a sterile animal facility that was maintained at 22 °C and at a 35 % relative humidity, with a 12-hr light/- dark cycle. All mice had ad libitum access to standard mouse chow and filtered water throughout the studies. All mice were allowed to accli- mate for a minimum of 10 day prior to any exposure being performed. All mice were weighed prior to the first dosing and again daily to assure that dosing volumes were constant over the course of the treatments. All animal work was done according to a University of Louisville IACUC protocol and with the approval of that committee IACUC #04050.
Single dose-level Ab Short-term (1-30 days) PFOS: Female BALB/c mice (8-wk-old) were purchased from the Jackson Laboratory (Bar Harbor, ME). All mice were housed in a sterile animal facility that was maintained at 22 °C and at a 35 % relative humidity, with a 12-hr light/- dark cycle. All mice had ad libitum access to standard mouse chow and filtered water throughout the studies. All mice were allowed to accli- mate for a minimum of 10 day prior to any exposure being performed. All mice were weighed prior to the first dosing and again daily to assure that dosing volumes were constant over the course of the treatments. All animal work was done according to a University of Louisville IACUC protocol and with the approval of that committee IACUC #04050.