Griffith and Long 1980

Data type(s)Animal bioassay
Full citationGriffith FD, and Long JE. 1980. Animal toxicity studies with ammonium perfluorooctanoate. Am Ind Hyg Assoc J 41(8): 576-583.
AbstractThese studies were conducted to evaluate the potential toxicity of ammonium perfluorooctanoate, a commercial surfactant. They include acute and subchronic feeding studies with rabbits, mice, rats and monkeys as well as in vitro mutagenicity assays with Salmonella typhimurium and Saccharomyces cerevisiae. The compound was non-irritating to the skin and moderately irritating to the eyes of rabbits. The rat oral LD50 was 540 mg/kg; no deaths resulted from a one hour rat inhalation exposure at a nominal concentration of 18.6 mg/L. All in vitro assays were negative. The liver was the target organ in rodents in both the 28 day and 90 day feeding studies with males showing a greater response than females. Serum and liver concentrations of organic fluorine were greater in male than in female rats. In a 90 day oral study in rhesus monkeys the gastrointestinal tract and the reticuloendothelial system were the sites of toxic effects. The gastrointestinal effects were attributed to the potent surface activity of the compound. Histopathological effects wer noted in the spleen, lymph nodes and bone marrow. Unlike the rats, sex related differences were not evident in the monkeys. Toxicological evaluations of ammonium perfluorooctanoate are continuing.
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Literature review tagsAnimal Study
COI reportedNot reported
Funding sourcenone reported
Study identifier{Griffith, 1980 #571}
Author contacted?
Author contact detailswe were not able to obtain an e-mail address for the authors and were not able to contact them.
Summary/extraction commentsData available:
observed for signs of toxicity; body weight; comprehensive hematology; comprehensive clinical chemistry; comprehensive urinalysis; gross pathologic examination; spleen weight; spleen/body weight ratio; liver weight; liver/body weight ratio; kidney weight; kidney/body weight ratio; adrenal gland weight; adrenal gland/body weight ratio; pituitary gland weight; pituitary gland/body weight ratio; histopathology, other tissues; thymus histopathology; bone marrow histopathology; spleen histopathology; lymph node histopathology; heart weight; heart/body weight ratio; testis weight; testis/body weight ratio; ovary weight; ovary/body weight ratio; brain weight; brain/body weight ratio; parathyroid gland weight; parathyroid gland/body weight ratio; thyroid gland weight; thyroid gland/body weight ratio; mortality

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Animal bioassay experiments

NameTypeComments
90-day rat Subchronic (30-90 days)
90-day monkey Subchronic (30-90 days)