Male and nulliparous female Wistar rats (90–120 days old) were obtained from colonies maintained under specific pathogen-free conditions from our breeding center of the Universidad Nacional del Sur, Bahía Blanca, Argentina. They were maintained under constant temperature (22° ± 1 °C) and under humidity (50–60%) conditions in a 12L:12D cycle (lights on at 7:00 a.m.) and with standard rodent pellet diet and filtered tap water ad libitum. In the evening of the proestrus day, they were housed overnight with the male rats. The presence of spermatozoa in the vaginal smears was registered as an index of pregnancy and it was referred to as gestational day 0 (GD 0). Pregnant females were housed individually in cages and were randomly assigned to one of the three following groups: control group (n = 10; filtered tap water), F treated group with 5 mg/l in filtered tap water (n = 10) and F treated group with 10 mg/l in filtered tap water (n = 10), equivalent to doses of 0.6 and 1.2 mg/kg, respectively. Animal care and handling were in accordance with the internationally accepted standard Guide for the Care and Use of Laboratory Animals as adopted and promulgated by the National Institute of Health. Experimental designs were also approved by the local standard for protecting animal’s welfare, Institutional Committee for the Care and Use of Experimental Animals of Universidad Nacional del Sur, Argentina. Number of animal protocols 020/2014 and 021/2014.