Trivedi 2007b
| Data type(s) | Animal bioassay |
|---|---|
| Full citation | Trivedi MH, Verma RJ, Chinoy NJ. 2007. Amelioration by black tea of sodium fluoride-induced changes in protein content of cerebral hemisphere, cerebellum and medulla oblongata in brain region of mice. Acta Poloniae Pharm 64: 221-225. |
| Abstract | Oral administration of sodium fluoride (NaF, 6 and 12 mg/kg body weight/day) to Swiss strain male albino mice for 30 days caused significant dose-dependant reduction in the content of acidic, basic, neutral, and total protein in cerebral hemisphere, cerebellum and medulla oblongata region of brain. After 30 days of NaF treatment, followed by withdrawal of treatment for 30 days, partial but significant amelioration occurred. Administration of 2% black tea extract alone for 30 days did not cause any significant effect. However, concurrent administration of NaF and black tea extract for 30 days caused significant amelioration in all parameters studied. |
| Reference hyperlink | |
| Literature review tags | Animal Study |
| COI reported | Authors report they have no COI |
| Funding source | Financial assistance under Gujarat Government Research Scholarship 2005-06 from the Gujarat Government, Gandhinagar, India |
| Study identifier | 389 |
| Author contacted? | true |
| Author contact details | Authors were contacted in September 2018 to obtain information for RoB assessment. No response was received to email request for clarification. |
| Summary/extraction comments | Data not extracted; mechanistic data: biochemical |
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