One hundred twenty Sprague–Dawley (SD) rats (half males and half females) with two months of age and an initial weight of 90–120 g were purchased from the Experimental Animal Center in Guizhou, China, and ethical permission for this study was obtained from the regional ethical committee for animal studies in Guizhou. Prior to treatment, these animals were acclimatized for one week in a housing facility with humidity ranging from 30 to 55% and a temperature of 22–25 °C. The rats were housed in stainless-steel cages suspended in stainless-steel racks and administered the diet and water ad libitum.

One hundred twenty Sprague–Dawley (SD) rats (half males and half females) with two months of age and an initial weight of 90–120 g were purchased from the Experimental Animal Center in Guizhou, China, and ethical permission for this study was obtained from the regional ethical committee for animal studies in Guizhou. Prior to treatment, these animals were acclimatized for one week in a housing facility with humidity ranging from 30 to 55% and a temperature of 22–25 °C. The rats were housed in stainless-steel cages suspended in stainless-steel racks and administered the diet and water ad libitum.