Confidence requires valid, reliable, and sensitive methods to assess the outcome and the methods should be applied consistently across groups.

Complete methods in protocol with some notes below:

Definitely low risk of bias criteria note: Training on all AGD measurements for all examiners using well-described methods (preferred is calipers), intra-rater, inter-rater reliability assessed, testosterone measured by HPLC, GC-MS, LC-MS or equilibrium dialysis
Probably low risk of bias criteria note: Description of training for AGD measurement methods with appropriate citation. Testosterone assay by RIA (not as reliable as methods listed in definitely low risk of bias but ok overall)
Probably high risk of bias criteria note: Indirect evidence that the outcome assessment method is using an insensitive instrument or AGD assessment without intra-rater or inter-rater reliability
Definitely high risk of bias criteria note: No description of AGD measurement methods or no description of testosterone laboratory assessment

Araki et al. 2014