| Dose-response |
Chronic (>90 days) |
Male cynomolgus
monkeys were obtained from
Covance
Research Products Inc. (Denver, PA) in August 1998. The mean age
of the monkeys, as
estimated by dentition, was 6 +/- 1 (SD) years and ranged
from 3 to 9 years.
The monkeys weighed 3.2 to 4.5 kg at initiation of treatment.
Monkeys were
acclimated for 35 days at Covance Laboratories in Madison,
Wisconsin
before initiation of treatment Each monkey was assigned a permanent
number upon arrival and identified
with a collar tag. The monkeys were
housed individually in suspended
stainless-steel cages. The animal room
was
environmentally controlled
to maintain 18 to 29°C, a relative humidity of 30 to 70%, and a 12-h light/dark cycle. |