OBJECTIVE: To determine the frequency of "signature" chromosomal abnormalities in oncology workers handling anticancer drugs.
METHODS: Peripheral blood from health care personnel (N = 109) was examined with probes for targets on chromosomes 5, 7, and 11. The effect of drug-handling frequency on chromosome abnormalities was assessed.
RESULTS: An excess of structural (0.18 vs 0.02; P = 0.04) and total abnormalities (0.29 vs 0.04; P = 0.01) of chromosome 5 was observed in the high-exposure group compared with the unexposed. Increased incidence rate ratios (IRRs) for abnormalities of chromosome 5 (IRR = 1.24; P = 0.01) and for either chromosome 5 or 7 (IRR = 1.20; P = 0.01) were obtained at 100 handling events. Effect sizes were augmented 2- to 4-fold when alkylating agent handling alone was considered.
CONCLUSIONS: Biologically important exposure to genotoxic drugs is apparently occurring in oncology work settings despite reported use of safety practices.

McDiarmid, 2010

Risk of bias

Epidemiological study populations

HAWC