Background: The serum microRNAs have been reported as potential biomarkers for hepatitis virus-related hepatocellular carcinoma (HCC); however, their role in aflatoxin B1 (AFB1)-related HCC to has not yet been evaluated.
Materials and Methods: We conducted a case-control study, including 366 HCC cases and 662 controls without any evidence of tumors, to identify and assess diagnostic and prognostic potential of serum microRNAs for AFB1-related HCC. The sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) were used to elucidate diagnostic performance, and to compare the microRNAs with α-fetoprotein (AFP) at a cutoff of 20 ng/mL (AFP20) and 400 ng/mL (AFP400).
Results: We found 8 differentially expressed microRNAs via the microRNA array analysis; however, only microRNA-4651 was further identified to detect AFB1-positive HCC but not AFB1-negative HCC. For AFB1-positive HCC, microRNA-4651 showed higher accuracy and sensitivity than AFP400 (AUC, 0.85 vs. 0.72; Sensitivity, 78.1% vs. 43.0%). Compared to AFP20, microRNA-4651 exhibited higher potential in identifying small-size (0.68 vs. 0.84 for AUC and 36.7% vs. 75.5% for sensitivity, respectively) and early-stage HCC (0.69 vs. 0.84 for AUC and 38.7% vs. 75.7% for sensitivity, respectively). Additionally, miR-4651 was also associated with HCC prognosis (hazard risk value, 2.67 for overall survival and 3.62 for tumor recurrence analysis).
Conclusions: These data suggest that serum microRNA-4651 may be a useful marker for HCC diagnosis and prognosis, especially AFB1-positive cases.

[Untagged]
━ Inclusion
━ ━ 1,3-butadiene
━ ━ ━ Mouse
━ ━ ━ ━ in vivo
━ ━ ━ ━ ━ DNA methylation
━ ━ ━ ━ ━ Histone modification
━ ━ 4-Aminobiphenyl
━ ━ ━ Human
━ ━ ━ ━ in vitro
━ ━ ━ ━ ━ microRNA
━ ━ ━ ━ ━ Histone modification
━ ━ Aflatoxins
━ ━ ━ Human
━ ━ ━ ━ in vitro
━ ━ ━ ━ ━ DNA methylation
━ ━ ━ ━ ━ microRNA
━ ━ ━ ━ ━ lncRNA
━ ━ ━ ━ in vivo
━ ━ ━ ━ ━ DNA methylation
━ ━ ━ ━ ━ microRNA
━ ━ ━ Mouse
━ ━ ━ ━ in vitro
━ ━ ━ ━ ━ microRNA
━ ━ ━ ━ in vivo
━ ━ ━ ━ ━ DNA methylation
━ ━ ━ ━ ━ Histone modification
━ ━ ━ Rat
━ ━ ━ ━ in vivo
━ ━ ━ ━ ━ DNA methylation
━ ━ ━ ━ ━ microRNA
━ ━ ━ Other
━ ━ ━ ━ in vitro
━ ━ ━ ━ ━ DNA methylation
━ ━ ━ ━ ━ Histone modification
━ ━ ━ ━ in vivo
━ ━ ━ ━ ━ DNA methylation
━ ━ ━ ━ ━ Histone modification
━ ━ Benzene
━ ━ ━ Human
━ ━ ━ ━ in vitro
━ ━ ━ ━ ━ DNA methylation
━ ━ ━ ━ in vivo
━ ━ ━ ━ ━ DNA methylation
━ ━ ━ ━ ━ Histone modification
━ ━ ━ ━ ━ microRNA
━ ━ ━ ━ ━ lncRNA
━ ━ ━ Mouse
━ ━ ━ ━ in vitro
━ ━ ━ ━ ━ DNA methylation
━ ━ ━ ━ in vivo
━ ━ ━ ━ ━ DNA methylation
━ ━ ━ ━ ━ Histone modification
━ ━ ━ ━ ━ microRNA
━ ━ ━ Rat
━ ━ ━ ━ in vitro
━ ━ ━ ━ ━ DNA methylation
━ ━ ━ ━ ━ Histone modification
━ ━ ━ ━ in vivo
━ ━ ━ ━ ━ DNA methylation
━ ━ Benzidine
━ ━ ━ Mouse
━ ━ ━ ━ in vivo
━ ━ ━ ━ ━ DNA methylation
━ ━ Benzo[a]pyrene
━ ━ ━ Human
━ ━ ━ ━ in vitro
━ ━ ━ ━ ━ DNA methylation
━ ━ ━ ━ ━ Histone modification
━ ━ ━ ━ ━ microRNA
━ ━ ━ ━ ━ lncRNA
━ ━ ━ ━ in vivo
━ ━ ━ ━ ━ DNA methylation
━ ━ ━ ━ ━ microRNA
━ ━ ━ Mouse
━ ━ ━ ━ in vitro
━ ━ ━ ━ ━ DNA methylation
━ ━ ━ ━ ━ Histone modification
━ ━ ━ ━ ━ microRNA
━ ━ ━ ━ in vivo
━ ━ ━ ━ ━ Histone modification
━ ━ ━ ━ ━ DNA methylation
━ ━ ━ ━ ━ microRNA
━ ━ ━ ━ ━ lncRNA
━ ━ ━ Rat
━ ━ ━ ━ in vivo
━ ━ ━ ━ ━ Histone modification
━ ━ ━ ━ ━ microRNA
━ ━ ━ Other
━ ━ ━ ━ in vitro
━ ━ ━ ━ ━ DNA methylation
━ ━ ━ ━ ━ Histone modification
━ ━ ━ ━ in vivo
━ ━ ━ ━ ━ DNA methylation
━ ━ Coke production
━ ━ ━ Human
━ ━ ━ ━ in vivo
━ ━ ━ ━ ━ microRNA
━ ━ ━ ━ ━ DNA methylation
━ ━ Formaldehyde
━ ━ ━ Human
━ ━ ━ ━ in vitro
━ ━ ━ ━ ━ DNA methylation
━ ━ ━ ━ ━ Histone modification
━ ━ ━ ━ ━ microRNA
━ ━ ━ Mouse
━ ━ ━ ━ in vivo
━ ━ ━ ━ ━ microRNA
━ ━ ━ Rat
━ ━ ━ ━ in vivo
━ ━ ━ ━ ━ microRNA
━ ━ ━ Other
━ ━ ━ ━ in vivo
━ ━ ━ ━ ━ microRNA
━ ━ ━ ━ in vitro
━ ━ ━ ━ ━ Histone modification
━ ━ MOCA
━ ━ ━ Rat
━ ━ ━ ━ in vitro
━ ━ ━ ━ ━ Histone modification
━ ━ Occupational exposure as a painter
━ ━ ━ Human
━ ━ ━ ━ in vivo
━ ━ ━ ━ ━ DNA methylation
━ ━ Sulfur Mustard
━ ━ ━ Human
━ ━ ━ ━ in vitro
━ ━ ━ ━ ━ DNA methylation
━ ━ ━ ━ ━ microRNA
━ ━ ━ ━ in vivo
━ ━ ━ ━ ━ microRNA
━ ━ ━ Mouse
━ ━ ━ ━ in vitro
━ ━ ━ ━ ━ microRNA
━ ━ Vinyl chloride
━ ━ ━ Human
━ ━ ━ ━ in vivo
━ ━ ━ ━ ━ DNA methylation
━ Exclusion
━ ━ no epigenetics
━ ━ ━ y-H2AX
━ ━ ━ histone-carcinogen binding
━ ━ not chemical of interest
━ ━ cannot access full text
━ ━ review or comment
━ ━ other
━ ━ ━ carcinogen binding to (existant) methylated cytosines
━ ━ ━ caricinogen binding and (existant) chromatin structure

References (1685 found)

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