spleen: relative weight

Endpoint name	spleen: relative weight
System	immune and lymphatic system
Organ	spleen
Effect	relative weight
Observation time	13 days
Additional tags	immune system observational immune measure spleen weight
Data reported?
Data extracted?
Values estimated?
Location in literature	Table 1
NOEL	5 mg/kg-day
LOEL	10 mg/kg-day
Monotonicity	visual appearance of monotonicity
Statistical test description	ANOVA
Trend result	not reported
Power notes	"underpowered to detect a change of 10% control" (sample size <50% of recommended) [calculated n=45; mean required-N calculation from all dose-groups] "appears to be adequately powered" (sample size met) to detect a change of 20% control [calculated n=12; mean required-N calculation from all dose-groups]

Dose (mg/kg-day)	Number of Animals	Response (%)	Standard Deviation
^a NOEL (No observed effect level) ^b Significantly different from control (p < 0.05) ^c LOEL (Lowest observed effect level)
0	6	0.46	0.04
5^a	6	0.43	0.06
10^b,c	6	0.38	0.02
20^b	6	0.27	0.06