viability in murine thymocytes

Endpoint Details

Endpoint nameviability in murine thymocytes
Systemimmune and lymphatic system
Organthymus
Effectnonneoplastic lesions
Observation time60 days
Additional tags
Data reported?
Data extracted?
Values estimated?
Location in literatureFigure 2
NOEL0.017 mg/kg-day
LOEL0.083 mg/kg-day
Monotonicityvisual appearance of monotonicity
Statistical test descriptionANOVA; Dunnett's t-test
Trend resultnot reported
Power notesPower cannot be calculated, computation failed.

Dataset

Dose (mg/kg-day)Number of AnimalsResponse (%)Standard Error
a NOEL (No observed effect level)
b Significantly different from control (p < 0.05)
c LOEL (Lowest observed effect level)
012100NR
0.017a12934.2
0.083b,c12903.4
0.833b12642.1

Plot

0.00.20.40.60.860708090100Dose = 0 mg/kg-day N = 12 Response = 100 % Standard Error = 0Dose = 0.0167 mg/kg-day N = 12 Response = 93 % Standard Error = 4.2Dose = 0.0833 mg/kg-day N = 12 Response = 90 % Standard Error = 3.4Dose = 0.8333 mg/kg-day N = 12 Response = 64 % Standard Error = 2.1*Statistically significant at 0.05*Statistically significant at 0.05Dose (mg/kg-day)Response (%)viability in murine thymocytesDosesLOELNOEL