IL-1 beta mRNA

Endpoint Details

Endpoint nameIL-1 beta mRNA
Systemimmune and lymphatic system
Organspleen
Effectinflammatory markers
Effect subtypetissue level
Diagnostic (as reported)RT-PCR
Observation time60 days
Additional tags
Data reported?
Data extracted?
Values estimated?
Location in literatureFigure 3B
NOEL0.008 mg/kg-day
LOEL0.417 mg/kg-day
Monotonicityvisual appearance of non-monotonicity
Statistical test descriptionANOVA; Dunnett's t-test
Trend resultnot reported
Power notes"underpowered to detect a change of 10% control" (sample size <50% of recommended) [calculated n=278; mean required-N calculation from all dose-groups] "underpowered to detect a change of 20% control" (sample size <50% of recommended) [calculated n=71; mean required-N calculation from all dose-groups]

Dataset

Dose (mg/kg-day)Number of AnimalsResponse (rel. mean)Standard Error
a NOEL (No observed effect level)
b Significantly different from control (p < 0.05)
c LOEL (Lowest observed effect level)
060.2680.051
0.008a60.230.038
0.01760.3290.042
0.08360.3710.032
0.417b,c60.450.052
0.833b60.5110.061
2.083b60.7410.045

Plot

0.00.51.01.52.00.10.20.30.40.50.60.70.80.9Dose = 0 mg/kg-day N = 6 Response = 0.268 rel. mean Standard Error = 0.051Dose = 0.0083 mg/kg-day N = 6 Response = 0.23 rel. mean Standard Error = 0.038Dose = 0.0167 mg/kg-day N = 6 Response = 0.329 rel. mean Standard Error = 0.042Dose = 0.0833 mg/kg-day N = 6 Response = 0.371 rel. mean Standard Error = 0.032Dose = 0.4167 mg/kg-day N = 6 Response = 0.45 rel. mean Standard Error = 0.052Dose = 0.8333 mg/kg-day N = 6 Response = 0.511 rel. mean Standard Error = 0.061Dose = 2.0833 mg/kg-day N = 6 Response = 0.741 rel. mean Standard Error = 0.045*Statistically significant at 0.05*Statistically significant at 0.05*Statistically significant at 0.05Dose (mg/kg-day)Response (rel. mean)IL-1 beta mRNADosesLOELNOEL