IL-1 beta levels

Endpoint Details

Endpoint nameIL-1 beta levels
Systemimmune and lymphatic system
Organperitoneal cavity
Effectinflammatory markers
Effect subtypein culture
Diagnostic (as reported)ELISA
Observation time60 days
Additional tags
Data reported?
Data extracted?
Values estimated?
Location in literatureTable III
NOEL0.017 mg/kg-day
LOEL0.083 mg/kg-day
Monotonicityvisual appearance of monotonicity
Statistical test descriptionANOVA; Dunnett's t-test
Trend resultnot reported
Power notes"underpowered to detect a change of 10% control" (sample size <50% of recommended) [calculated n=275; mean required-N calculation from all dose-groups] "underpowered to detect a change of 20% control" (sample size <50% of recommended) [calculated n=70; mean required-N calculation from all dose-groups]

Dataset

Dose (mg/kg-day)Number of AnimalsResponse (pg/mL)Standard Error
a NOEL (No observed effect level)
b Significantly different from control (p < 0.05)
c LOEL (Lowest observed effect level)
06106.3422.13
0.0086114.8116.35
0.017a6161.320.37
0.083b,c6199.8423.65
0.417b6235.9521.88
0.833b6303.2525.16
2.083b6372.6333.64

Plot

0.00.51.01.52.00100200300400500Dose = 0 mg/kg-day N = 6 Response = 106.34 pg/mL Standard Error = 22.13Dose = 0.0083 mg/kg-day N = 6 Response = 114.81 pg/mL Standard Error = 16.35Dose = 0.0167 mg/kg-day N = 6 Response = 161.3 pg/mL Standard Error = 20.37Dose = 0.0833 mg/kg-day N = 6 Response = 199.84 pg/mL Standard Error = 23.65Dose = 0.4167 mg/kg-day N = 6 Response = 235.95 pg/mL Standard Error = 21.88Dose = 0.8333 mg/kg-day N = 6 Response = 303.25 pg/mL Standard Error = 25.16Dose = 2.0833 mg/kg-day N = 6 Response = 372.63 pg/mL Standard Error = 33.64*Statistically significant at 0.05*Statistically significant at 0.05*Statistically significant at 0.05*Statistically significant at 0.05Dose (mg/kg-day)Response (pg/mL)IL-1 beta levelsDosesLOELNOEL