peritoneal cavity macrophages

Endpoint Details

Endpoint nameperitoneal cavity macrophages
Systemimmune and lymphatic system
Effectleukocyte or lymphocyte phenotyping: peritoneal cavity
Observation time60 days
Additional tags
Data reported?
Data extracted?
Values estimated?
Location in literatureTable II
NOEL0.008 mg/kg-day
LOEL0.017 mg/kg-day
Monotonicityvisual appearance of monotonicity
Statistical test descriptionANOVA; Dunnett's t-test
Trend resultnot reported
Power notes"underpowered to detect a change of 10% control" (sample size is 75% to <100% of recommended) [calculated n=7; mean required-N calculation from all dose-groups] "appears to be adequately powered" (sample size met) to detect a change of 20% control [calculated n=3; mean required-N calculation from all dose-groups]

Dataset

Dose (mg/kg-day)Number of AnimalsResponse (%)Standard Error
a NOEL (No observed effect level)
b Significantly different from control (p < 0.05)
c LOEL (Lowest observed effect level)
0675.281.23
0.008a679.761.86
0.017b,c681.331.49
0.083b682.141.63
0.417b683.241.71
0.833b684.21.35
2.083b686.951.12

Plot

0.00.51.01.52.072747678808284868890Dose = 0 mg/kg-day N = 6 Response = 75.28 % Standard Error = 1.23Dose = 0.0083 mg/kg-day N = 6 Response = 79.76 % Standard Error = 1.86Dose = 0.0167 mg/kg-day N = 6 Response = 81.33 % Standard Error = 1.49Dose = 0.0833 mg/kg-day N = 6 Response = 82.14 % Standard Error = 1.63Dose = 0.4167 mg/kg-day N = 6 Response = 83.24 % Standard Error = 1.71Dose = 0.8333 mg/kg-day N = 6 Response = 84.2 % Standard Error = 1.35Dose = 2.0833 mg/kg-day N = 6 Response = 86.95 % Standard Error = 1.12*Statistically significant at 0.05*Statistically significant at 0.05*Statistically significant at 0.05*Statistically significant at 0.05*Statistically significant at 0.05Dose (mg/kg-day)Response (%)peritoneal cavity macrophagesDosesLOELNOEL