neutrophils

Endpoint Details

Endpoint nameneutrophils
Systemhematologic
Effectleukocyte differential
Observation time49 days
Data reported?
Data extracted?
Values estimated?
Location in literatureAppendix 1 from complete study report
NOEL30 mg/kg-day
MonotonicityN/A, single dose level study
Statistical test descriptionSteel test
Power notes"underpowered to detect a change of 10% control" (sample size <50% of recommended) [calculated n=303; mean required-N calculation from all dose-groups] "underpowered to detect a change of 20% control" (sample size <50% of recommended) [calculated n=77; mean required-N calculation from all dose-groups]

Dataset

Dose (mg/kg-day)Number of AnimalsResponse (%WBC)Standard Deviation
a NOEL (No observed effect level)
0912.44.6
30a1013.76.8

Plot

05101520253081012141618Dose = 0 mg/kg-day N = 9 Response = 12.4 %WBC Standard Deviation = 4.6Dose = 30 mg/kg-day N = 10 Response = 13.7 %WBC Standard Deviation = 6.8Dose (mg/kg-day)Response (%WBC)neutrophilsDosesNOEL