thymus: relative weight

Endpoint Details

Endpoint namethymus: relative weight
Systemimmune and lymphatic system
Organthymus
Effectrelative weight
Observation time28 days
Additional tags
Data reported?
Data extracted?
Values estimated?
Location in literatureAppendix 1 from complete study report (publication only stated not significant)
NOEL30 mg/kg-day
MonotonicityN/A, single dose level study
Statistical test descriptionANOVA; Dunnett's test
Power notes"underpowered to detect a change of 10% control" (sample size <50% of recommended) [calculated n=32; mean required-N calculation from all dose-groups] "appears to be adequately powered" (sample size met) to detect a change of 20% control [calculated n=9; mean required-N calculation from all dose-groups]

Dataset

Dose (mg/kg-day)Number of AnimalsResponse (%)Standard Deviation
a NOEL (No observed effect level)
0100.180.025
30a100.190.026

Plot

0510152025300.160.170.180.190.200.21Dose = 0 mg/kg-day N = 10 Response = 0.18 % Standard Deviation = 0.025Dose = 30 mg/kg-day N = 10 Response = 0.19 % Standard Deviation = 0.026Dose (mg/kg-day)Response (%)thymus: relative weightDosesNOEL