cortisol

Endpoint Details

Endpoint namecortisol
Systemendocrine system
Effectcortisol
Observation time21 days
Data reported?
Data extracted?
Values estimated?
Location in literatureTable 5
LOEL0.1 mg/L
MonotonicityN/A, single dose level study
Statistical test descriptionone-way ANOVA after testing for normality and variance homogeneity followed by Dunnet's test
Power notes"underpowered to detect a change of 10% control" (sample size is 75% to <100% of recommended) [calculated n=6; mean required-N calculation from all dose-groups] "appears to be adequately powered" (sample size met) to detect a change of 20% control [calculated n=3; mean required-N calculation from all dose-groups]

Dataset

Dose (mg/L)Number of AnimalsResponse (ng/g)Standard Deviation
a Significantly different from control (p < 0.05)
b LOEL (Lowest observed effect level)
05195.866.93
0.1a,b585.755.27

Plot

0.000.020.040.060.080.1080100120140160180200Dose = 0 mg/L N = 5 Response = 195.86 ng/g Standard Deviation = 6.93Dose = 0.1 mg/L N = 5 Response = 85.75 ng/g Standard Deviation = 5.27*Statistically significant at 0.05Dose (mg/L)Response (ng/g)cortisolDosesLOEL