thymus DN (CD4-/CD8-)

Endpoint Details

Endpoint namethymus DN (CD4-/CD8-)
Systemimmune and lymphatic system
Organthymus
Effectleukocyte or lymphocyte phenotyping
Observation time61 days
Additional tags
Data reported?
Data extracted?
Values estimated?
Location in literatureTable 3
NOEL0.833 mg/kg-day
LOEL2.083 mg/kg-day
Monotonicityvisual appearance of monotonicity
Statistical test descriptionone-way ANOVA followed by Dunnett's t-test
Trend resultnot reported
Power notes"underpowered to detect a change of 10% control" (sample size <50% of recommended) [calculated n=360; mean required-N calculation from all dose-groups] "underpowered to detect a change of 20% control" (sample size <50% of recommended) [calculated n=91; mean required-N calculation from all dose-groups]

Dataset

Dose (mg/kg-day)Number of AnimalsResponse (cellsx10^6)Standard Error
a NOEL (No observed effect level)
b Significantly different from control (p < 0.05)
c LOEL (Lowest observed effect level)
0106.640.92
0.008106.810.74
0.083105.770.85
0.417105.120.41
0.833a104.390.53
2.083b,c103.650.37

Plot

0.00.51.01.52.03456789Dose = 0 mg/kg-day N = 10 Response = 6.64 cellsx10^6 Standard Error = 0.92Dose = 0.00833 mg/kg-day N = 10 Response = 6.81 cellsx10^6 Standard Error = 0.74Dose = 0.08333 mg/kg-day N = 10 Response = 5.77 cellsx10^6 Standard Error = 0.85Dose = 0.41667000000000004 mg/kg-day N = 10 Response = 5.12 cellsx10^6 Standard Error = 0.41Dose = 0.83333 mg/kg-day N = 10 Response = 4.39 cellsx10^6 Standard Error = 0.53Dose = 2.08333 mg/kg-day N = 10 Response = 3.65 cellsx10^6 Standard Error = 0.37*Statistically significant at 0.05Dose (mg/kg-day)Response (cellsx10^6)thymus DN (CD4-/CD8-)DosesLOELNOEL