platelet count

Endpoint Details

Endpoint nameplatelet count
Systemhematologic
Effectplatelet count and morphologic assessment
Observation time28 days
Additional tags
Data reported?
Data extracted?
Values estimated?
Location in literatureTable 2
NOEL0.166 mg/kg-day
MonotonicityN/A, no effects detected
Statistical test descriptionANOVA followed by Dunnett's T-test or Student's t-test
Power notes"underpowered to detect a change of 10% control" (sample size <50% of recommended) [calculated n=22; mean required-N calculation from all dose-groups] "underpowered to detect a change of 20% control" (sample size is 75% to <100% of recommended) [calculated n=7; mean required-N calculation from all dose-groups]

Dataset

Dose (mg/kg-day)Number of AnimalsResponse (x1000/uL)Standard Error
a NOEL (No observed effect level)
05105748.6
0.0035109946.8
0.0175115435.8
0.0335105553.2
0.166a5108636.2

Plot

0.000.050.100.159009501,0001,0501,1001,1501,2001,2501,300Dose = 0 mg/kg-day N = 5 Response = 1057 x1000/uL Standard Error = 48.6Dose = 0.00331 mg/kg-day N = 5 Response = 1099 x1000/uL Standard Error = 46.8Dose = 0.0166 mg/kg-day N = 5 Response = 1154 x1000/uL Standard Error = 35.8Dose = 0.033100000000000004 mg/kg-day N = 5 Response = 1055 x1000/uL Standard Error = 53.2Dose = 0.166 mg/kg-day N = 5 Response = 1086 x1000/uL Standard Error = 36.2Dose (mg/kg-day)Response (x1000/uL)platelet countDosesNOEL