Male cynomolgus monkeys were obtained from Covance Research Products Inc. (Denver, PA) in August 1998. The mean age of the monkeys, as estimated by dentition, was 6 +/- 1 (SD) years and ranged from 3 to 9 years. The monkeys weighed 3.2 to 4.5 kg at initiation of treatment. Monkeys were acclimated for 35 days at Covance Laboratories in Madison, Wisconsin before initiation of treatment Each monkey was assigned a permanent number upon arrival and identified with a collar tag. The monkeys were housed individually in suspended stainless-steel cages. The animal room was environmentally controlled to maintain 18 to 29°C, a relative humidity of 30 to 70%, and a 12-h light/dark cycle.

kidney weight

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HAWC