spleen: relative weight

Endpoint Details

Endpoint namespleen: relative weight
Systemimmune and lymphatic system
Organspleen
Effectrelative weight
Observation time14 days
Additional tags
Data reported?
Data extracted?
Values estimated?
Location in literatureTable 2
NOEL5 mg/kg-day
LOEL20 mg/kg-day
Monotonicityvisual appearance of monotonicity
Statistical test descriptionone-way ANOVA
Power notes"underpowered to detect a change of 10% control" (sample size <50% of recommended) [calculated n=191; mean required-N calculation from all dose-groups] "underpowered to detect a change of 20% control" (sample size <50% of recommended) [calculated n=49; mean required-N calculation from all dose-groups]

Dataset

Dose (mg/kg-day)Number of AnimalsResponse (g/g x100)Standard Error
a NOEL (No observed effect level)
b Significantly different from control (p < 0.05)
c LOEL (Lowest observed effect level)
080.41810.04
5a80.34010.05
20b,c80.25510.02

Plot

051015200.200.250.300.350.400.450.500.55Dose = 0 mg/kg-day N = 8 Response = 0.4181 g/g x100 Standard Error = 0.04Dose = 5 mg/kg-day N = 8 Response = 0.3401 g/g x100 Standard Error = 0.05Dose = 20 mg/kg-day N = 8 Response = 0.2551 g/g x100 Standard Error = 0.02*Statistically significant at 0.05Dose (mg/kg-day)Response (g/g x100)spleen: relative weightDosesLOELNOEL