Fairley 200757624
|
Dose-response452
|
Female BALB/c mice574
|
spleen: absolute weight8715
|
ppm |
- |
- |
- |
- |
Fairley 200757624
|
Dose-response452
|
Female BALB/c mice574
|
liver weight8716
|
ppm |
- |
- |
- |
- |
Fairley 200757624
|
Dose-response452
|
Female BALB/c mice574
|
body weight8717
|
ppm |
- |
- |
- |
- |
Fairley 200757624
|
Dose-response452
|
Female BALB/c mice574
|
thymus cellularity8718
|
ppm |
- |
- |
- |
- |
Fairley 200757624
|
Dose-response452
|
Female BALB/c mice574
|
spleen cellularity8719
|
ppm |
- |
- |
- |
- |
Fairley 200757624
|
hypersensitivity (PFOA day 1-4; 27 day observation)453
|
Female BALB/c mice575
|
liver weight8721
|
ppm |
- |
- |
- |
- |
Fairley 200757624
|
hypersensitivity (PFOA day 1-4; 27 day observation)453
|
Female BALB/c mice575
|
total serum IgE8727
|
ppm |
- |
- |
- |
- |
Fairley 200757624
|
hypersensitivity (PFOA day 1-4; 27 day observation)453
|
Female BALB/c mice575
|
OVA-specific IgE8729
|
ppm |
- |
- |
- |
- |
Fairley 200757624
|
hypersensitivity (PFOA day 1-4; 27 day observation)453
|
Female BALB/c mice575
|
pleiotropic inflammatory response in the lungs (mild)8730
|
ppm |
- |
- |
- |
- |
Fairley 200757624
|
hypersensitivity (PFOA day 1-4; 27 day observation)453
|
Female BALB/c mice575
|
eosinophil infiltration in the lungs (mild)8731
|
ppm |
- |
- |
- |
- |
Fairley 200757624
|
hypersensitivity (PFOA day 1-4; 27 day observation)453
|
Female BALB/c mice575
|
mucin in the lungs (increased in cells but not in airways)8732
|
ppm |
- |
- |
- |
- |
Fairley 200757624
|
hypersensitivity (PFOA day 1-4; 27 day observation)453
|
Female BALB/c mice575
|
pleiotropic inflammatory response in the lungs (moderate)8733
|
ppm |
- |
- |
- |
- |
Fairley 200757624
|
hypersensitivity (PFOA day 1-4; 27 day observation)453
|
Female BALB/c mice575
|
pleiotropic inflammatory response in the lungs (high)8734
|
ppm |
- |
- |
- |
- |
Fairley 200757624
|
hypersensitivity (PFOA day 1-4; 27 day observation)453
|
Female BALB/c mice575
|
eosinophil infiltration in the lungs (moderate)8735
|
ppm |
- |
- |
- |
- |
Fairley 200757624
|
hypersensitivity (PFOA day 1-4; 27 day observation)453
|
Female BALB/c mice575
|
eosinophil infiltration in the lungs (high)8736
|
ppm |
- |
- |
- |
- |
Fairley 200757624
|
hypersensitivity (PFOA day 1-4; 27 day observation)453
|
Female BALB/c mice575
|
mucin in the lungs (increased in cells and increased mucous in airways)8737
|
ppm |
- |
- |
- |
- |
Fairley 200757624
|
hypersensitivity (PFOA day 1-4; 27 day observation)453
|
Female BALB/c mice575
|
mucin in the lungs (increased in cells expressing a greater cell height into the airway and width with mucous in airways)8738
|
ppm |
- |
- |
- |
- |
Fairley 200757624
|
hypersensitivity (PFOA day 1-4; 27 day observation)453
|
Female BALB/c mice575
|
nonspecific airway hyperactivity response to methacholine exposure8739
|
ppm |
- |
- |
- |
- |
Fairley 200757624
|
hypersensitivity (PFOA day 1-4; 27 day observation)453
|
Female BALB/c mice575
|
spleen B220+ cells8740
|
ppm |
- |
- |
- |
- |
Fairley 200757624
|
hypersensitivity (PFOA day 1-4; 27 day observation)453
|
Female BALB/c mice575
|
CD3, CD4, CD8 splenocytes and thymocytes8741
|
ppm |
- |
- |
- |
- |
Fairley 200757624
|
hypersensitivity (PFOA day 1-4; 27 day observation)453
|
Female BALB/c mice575
|
OVA-specific airway hyperreactivity (AUC)8744
|
ppm |
- |
- |
- |
- |
Fairley 200757624
|
hypersensitivity (PFOA day 1-4; 27 day observation)453
|
Female BALB/c mice575
|
OVA-specific airway hyperreactivity8745
|
ppm |
- |
- |
- |
- |
Fairley 200757624
|
hypersensitivity (PFOA day 1-4; 14 day observation)779
|
Female BALB/c mice1628
|
total serum IgE16726
|
ppm |
- |
- |
- |
- |
Fairley 200757624
|
hypersensitivity (PFOA day 1-4; 14 day observation)779
|
Female BALB/c mice1628
|
total serum IgE16727
|
ppm |
- |
- |
- |
- |
Fairley 200757624
|
hypersensitivity (PFOA day 1-4; 14 day observation)779
|
Female BALB/c mice1628
|
OVA-specific IgE16728
|
ppm |
- |
- |
- |
- |