Male C57BL/6 mice

Available endpoints

↑ Endpoint Organ Obs. TimeDose [%]
00.0020.0050.010.02
N--44444
serum AH50-10 days26 ± 1.825 ± 1.4 (-4%)24 ± 1.2 (-8%)19 ± 2.4 (-27%)a8 ± 1.4 (-69%)b,c
serum C3-10 days4.4 ± 2.26.9 ± 1.8 (57%)4.7 ± 0.6 (7%)4.7 ± 1.2 (7%)a2.2 ± 0.2 (-50%)b,c
serum CH50-10 days33 ± 1053 ± 20 (61%)36 ± 4 (9%)26 ± 6 (-21%)a8 ± 1 (-76%)b,c
spleen: relative weightspleen10 days0.29 ± 0.020.26 ± 0.02 (-10%)0.27 ± 0.04 (-7%)a0.22 ± 0.02 (-24%)b,c0.17 ± 0.02 (-41%)b
thymus: relative weightthymus10 days0.19 ± 0.0060.18 ± 0 (-5%)0.16 ± 0.02 (-16%)a0.09 ± 0.002 (-53%)b,c0.03 ± 0.006 (-84%)b
a NOEL (No observed effect level)
b Significantly different from control (p < 0.05)
c LOEL (Lowest observed effect level)

Additional endpoints

Endpoints which have no dose-response data extracted.