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  • PFOA/PFOS Exposure and Immunotoxicity (2016)
    • Literature review
    • Study list
    • Risk of bias
    • Endpoint list
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    • Downloads
  • About
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  1. Public Assessments
  2. PFOA/PFOS Exposure and Immunotoxicity (2016)
  3. Rosen 2010
  4. PFOS_PPAR
  5. Male Ppara-tm1Gonz/J mice

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Male Ppara-tm1Gonz/J mice

Available endpoints

No endpoints are available with dose-response data.

Additional endpoints

Endpoints which have no dose-response data extracted.

  • total liver weight
  • relative liver weight
  • liver histopathology
  • gene fold change: lipid metabolism genes
  • gene fold change: proteasome biogenesis genes
  • gene fold change: xenobiotic metabolism genes
  • gene fold change: cholesterol biosynthesis genes
  • gene fold change: oxidative phosphorylation/electron transport genes
  • gene fold change: ribosome biogenesis genes
  • gene expression: markers of PPARalpha transactivation
  • gene expression of selected genes: Srebf2, Pgc-1a, Nrf2, Ndufa5, Lss, Cyp2b10, Cyp4a14, Cyp7a1
  • gene fold change: inflammatory response genes
  • gene fold change: peroxisome biogenesis genes
HAWC

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last updated: January 16, 2025