Female Crl:CD(SD)IGS BR rat
Available endpoints
| ↑ Endpoint | Organ | Obs. Time | Dose [mg/kg-day] (ppm) | ||||
|---|---|---|---|---|---|---|---|
| 0 (0) | 0.04 (0.5) | 0.15 (2) | 0.4 (5) | 1.56 (20) | |||
| N | - | - | 10 | 10 | 10 | 10 | 10 |
| non-segmented neutrophils (N-SEG) | - | 14 weeks | 1 ± 0.5 | 1 ± 0.5 (0%) | 0.7 ± 0.2 (-30%) | 0.9 ± 0.6 (-10%) | 1 ± 0.6 (0%)a |
| a NOEL (No observed effect level) | |||||||
Additional endpoints
Endpoints which have no dose-response data extracted.
- body weight
- food consumption
- food efficiency
- erythrocyte count
- leukocyte count
- platelet count
- hemoglobin
- hematocrit
- mean corpuscular volume
- mean corpuscular hemoglobin concentration
- mean corpuscular hemoglobin
- leukocyte differential
- blood cell morphology
- alanine aminotransferase (ALT)
- aspartate aminotransferase (AST)
- gamma-glutamyl transpeptidase (GGT)
- glucose
- blood urea nitrogen (BUN)
- calcium
- phosphate
- bilirubin
- cholesterol
- creatinine
- total protein
- albumin
- globulin
- sodium
- potassium
- chloride
- multiple urine parameters: pH, protein, bilirubin, blood, urobilinogen, ketones, glucose, Na, K
- liver/body weight
- liver histopathology
- liver palmitoyl CoA oxidase (PCoAO) activity
- liver cell proliferation
- spleen/body weight
- spleen histopathology
- mesenteric lymph node histopathology
- histopathology of the adrenals, brain, eyes, kidney, pancreas, and reproductive organs