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    • Literature review
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  2. PFOA/PFOS Exposure and Immunotoxicity (2016)
  3. Minata 2010
  4. PFOA_wildtype
  5. Male 129S4/SvlmJ mice

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Male 129S4/SvlmJ mice

Available endpoints

↑ Endpoint Organ Obs. TimeDose [mmol/kg-day]
00.0130.0250.05
N--9101010
TNF-alpha mRNA levels in liver (normalized to GAPDH)-4 weeks2.25 ± 1.81.73 ± 1.35 (-23%)1.93 ± 1.73 (-14%)1.86 ± 1.54 (-17%)a
a NOEL (No observed effect level)

Additional endpoints

Endpoints which have no dose-response data extracted.

  • gross body weight (start of experiment)
  • body weight - liver weight (start of experiment)
  • gross body weight (4 weeks)
  • body weight - liver weight (4 weeks)
  • body weight gain excluded liver (4 weeks)
  • relative liver weight (4 weeks)
  • liver histology
  • AST
  • ALT
  • T-Bil
  • TBA
  • T-Cho
  • TG
  • BSEP protein levels
  • MRP2 protein levels
  • 8-OHdG levels in liver
  • Mdr2 mRNA levels in liver
  • biliary total bile acid/phospholipid (BA/PL) ratio in liver
  • liver weight (4 weeks)
HAWC

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last updated: January 16, 2025