Male 129S4/SvlmJ mice
Available endpoints
↑ Endpoint | Organ | Obs. Time | Dose [mmol/kg-day] | |||
---|---|---|---|---|---|---|
0 | 0.013 | 0.025 | 0.05 | |||
N | - | - | 9 | 10 | 10 | 10 |
TNF-alpha mRNA levels in liver (normalized to GAPDH) | - | 4 weeks | 2.25 ± 1.8 | 1.73 ± 1.35 (-23%) | 1.93 ± 1.73 (-14%) | 1.86 ± 1.54 (-17%)a |
a NOEL (No observed effect level) |
Additional endpoints
Endpoints which have no dose-response data extracted.
- gross body weight (start of experiment)
- body weight - liver weight (start of experiment)
- gross body weight (4 weeks)
- body weight - liver weight (4 weeks)
- body weight gain excluded liver (4 weeks)
- relative liver weight (4 weeks)
- liver histology
- AST
- ALT
- T-Bil
- TBA
- T-Cho
- TG
- BSEP protein levels
- MRP2 protein levels
- 8-OHdG levels in liver
- Mdr2 mRNA levels in liver
- biliary total bile acid/phospholipid (BA/PL) ratio in liver
- liver weight (4 weeks)