F1 female Wistar rats (90-day old)

↑ Endpoint	Organ	Obs. Time	Dose [mg/kg-day] (ppm)
↑ Endpoint	Organ	Obs. Time	0 (0)	0.27 (2.26)	0.54 (4.52)
N	-	-	10	10	10
elevated plus maze (open arm entries)	-	90 PND	21.2 ± 10.056	39.9 ± 12.048 (88%)^a,b	46.1 ± 16.064 (117%)^a
elevated plus maze (time in open arms)	-	90 PND	15.1 ± 12.175	32.7 ± 12.175 (117%)^c,b	46.5 ± 16.222 (208%)^a
open field (defecation)	-	90 PND	0 ± 0	1.9 ± 3.795	0.5 ± 0.791^d
open field (grooming events)	-	90 PND	2.8 ± 1.581	6.2 ± 3.637 (121%)^c,b	3.5 ± 1.739 (25%)
open field (rearing events, 15 min)	-	90 PND	80.5 ± 6.894	82.1 ± 13.819 (2%)	74.9 ± 13.819 (-7%)^d
open field (squares crossed, 15 min)	-	90 PND	338 ± 55.656	226 ± 48.699 (-33%)^a,b	218 ± 41.742 (-36%)^a
^a Significantly different from control (p < 0.001) ^b LOEL (Lowest observed effect level) ^c Significantly different from control (p < 0.01) ^d NOEL (No observed effect level)