Combined Wistar rat (F1)

↑ Endpoint	Organ	Obs. Time	Dose [mg/kg-day] (ppm)
↑ Endpoint	Organ	Obs. Time	0.13 (0.6)	0.21 (1)	1.06 (5)	5.29 (25)
N	-	-	40	40	40	40
Morris water maze (number of errors, acquisition)	-	PND 45	4.3 ± 1.3	4 ± 1.6 (-7%)	4.8 ± 1.2 (12%)^a	5.2 ± 1.3 (21%)^b,c
Morris water maze (time to find platform, probe test)	-	PND 45	7.09 ± 2.18	8.28 ± 2.71 (17%)	8.63 ± 2.98 (22%)^a	9.54 ± 4.16 (35%)^b,c
activity time (developmental phase I)	-	PND 45	6.1 ± 1.2	6.4 ± 0.7 (5%)	7.9 ± 0.9 (30%)	7.4 ± 1.4 (21%)^a
activity time (developmental phase II)	-	PND 45	10.1 ± 1.2	9.5 ± 0.5 (-6%)	10.1 ± 1.1 (0%)	9.8 ± 0.9 (-3%)^a
activity time (developmental phase III)	-	PND 45	13.6 ± 0.9	13.5 ± 0.8 (-1%)^a	14.9 ± 1.1 (10%)^b,c	13.9 ± 0.5 (2%)
open field (face scrubbing events, 9 min)	-	PND 30	3.9 ± 3.3	2.3 ± 2.1 (-41%)^b,c	2 ± 1.7 (-49%)^b	2 ± 1.4 (-49%)^b
open field (latency period, 9 min)	-	PND 30	4.36 ± 2.7	3.93 ± 2.3 (-10%)	6.22 ± 5.5 (43%)	5.05 ± 3.1 (16%)^a
open field (rearing events, 9 min)	-	PND 30	33.5 ± 13.2	39.8 ± 13.6 (19%)	24.9 ± 15.2 (-26%)	28 ± 12.2 (-16%)^a
open field (squares traveled, 9 min)	-	PND 30	141.5 ± 29.5	145.5 ± 29.3 (3%)^a	114.3 ± 26.5 (-19%)^b,c	129.9 ± 30 (-8%)
^a NOEL (No observed effect level) ^b Significantly different from control (p < 0.05) ^c LOEL (Lowest observed effect level)

Endpoints which have no dose-response data extracted.