male Wistar rats

Available endpoints

↑ Endpoint Organ Obs. TimeDose [mg/kg-day] (ppm)
0.07 (0.5)14.75 (100)
N--66
T-maze (exploratory activity)-adult15.67 ± 1.758.83 ± 1.16 (-44%)a,b
T-maze (number of correct choices)-adult75.69 ± 4.8755.55 ± 4.3 (-27%)a,b
T-maze (spontaneous alteration test, choices of more frequently chosen arm)-adult52.77 ± 4.369.44 ± 3.4 (32%)a,b
passive avoidance (exploration, number of crossings)-adult12.17 ± 1.4711.83 ± 1.47 (-3%)c
passive avoidance (exploration, time in small compartment)-adult392.5 ± 20.4398.3 ± 13.6 (1%)c
passive avoidance (retention, number of crossings)-adult7 ± 1.4113 ± 13 (86%)a,b
passive avoidance (retention, time in small compartment)-adult135.7 ± 15.6250.8 ± 21.9 (85%)a,b
a Significantly different from control (p < 0.001)
b LOEL (Lowest observed effect level)
c NOEL (No observed effect level)